School of Materials Engineering, Purdue University, 701 West Stadium Avenue, West Lafayette, Indiana 47907, United States.
Biomacromolecules. 2011 Jan 10;12(1):50-6. doi: 10.1021/bm1009624. Epub 2010 Dec 15.
The development of polymers that are both bactericidal and biocompatible would have many applications and are currently of substantial research interest. It is well known that polymers of alkyl-quaternized poly(4-vinylpyridine) are known to be effective against a wide range of microbes: when copolymerized with monomers that form biocompatible materials, they has also been shown to possess biocompatible properties. However, the relationship of the various physical and chemical properties of these polymers and copolymers with the antibacterial and biocompatible properties remains poorly understood: maximizing the selectivity and performance of these materials is absolutely needed before they have the potential for commercial applications. Maximizing the performance will require a complete understanding of the effect of physical and chemical adjustments on these quaternized polymer bactericides. This article seeks to explore and characterize the effect of one specific property, steric hindrance, on the copolymers' antibacterial and biocompatible properties. We have thus synthesized and characterized a new class of copolymers from 2-vinylpyridine and poly(ethylene glycol) methyl ether methacrylate, measured its bactericidal and biocompatible properties, and compared its performance to chemically similar but sterically different polymer bactericides. This work thereby enables both a greater understanding of the properties of the 2-vinylpyridine copolymers and an improved understanding of the material properties that are vital for the development of antibacterial polymers.
开发既具有杀菌性又具有生物相容性的聚合物将有许多应用，并且目前是大量研究的关注点。众所周知，烷基季铵化聚（4-乙烯基吡啶）聚合物对多种微生物具有有效作用：当与形成生物相容材料的单体共聚时，也表现出具有生物相容的性质。然而，这些聚合物和共聚物的各种物理和化学性质与抗菌和生物相容性质之间的关系仍然知之甚少：在这些材料具有商业应用潜力之前，绝对需要最大限度地提高这些材料的选择性和性能。要提高性能，就需要全面了解物理和化学调整对这些季铵化聚合物杀菌剂的影响。本文旨在探讨和表征一种特定性质，即空间位阻，对共聚物的抗菌和生物相容性质的影响。因此，我们合成并表征了一类新的共聚物，由 2-乙烯基吡啶和聚（乙二醇）甲基醚甲基丙烯酸酯组成，测量了其杀菌和生物相容性质，并将其性能与化学性质相似但空间位阻不同的聚合物杀菌剂进行了比较。这项工作使我们能够更好地理解 2-乙烯基吡啶共聚物的性质，并更好地理解对于开发抗菌聚合物至关重要的材料性质。
