6-（对羟基苯基偶氮）尿嘧啶对噬菌体IG 1的作用
Action of 6-(p-hydroxyphenylazo)-uracil on bacteriophage IG 1.
作者信息
Fernandes R M, de Lencastre H, Archer L J
机构信息
Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Monte de Caparica, Portugal.
出版信息
Arch Virol. 1990;113(3-4):177-81. doi: 10.1007/BF01316671.
IG 1, a temperate phage of Bacillus subtilis, is strongly induced from its lysogens by 6-(p-hydroxyphenylazo)-uracil, an azopyrimidine known as selectively inhibiting the B. subtilis DNA polymerase III. IG 1 phages originated either by induction or infection multiply, abundantly, in the presence of that azopyrimidine, in spite of the drastic decline of cell viability. Chloramphenicol completely suppresses the induction effect and also blocks the formation of spontaneously induced phage particles.
IG1是枯草芽孢杆菌的一种温和噬菌体，6-(对羟基苯偶氮)-尿嘧啶可强烈诱导其溶原菌产生这种噬菌体。6-(对羟基苯偶氮)-尿嘧啶是一种偶氮嘧啶，已知可选择性抑制枯草芽孢杆菌DNA聚合酶III。IG1噬菌体无论是通过诱导还是感染产生，在这种偶氮嘧啶存在的情况下都会大量繁殖，尽管细胞活力急剧下降。氯霉素完全抑制诱导效应，也会阻止自发诱导的噬菌体颗粒的形成。
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