New England Research Institutes, Watertown, Massachusetts 02472, USA.
J Urol. 2011 Mar;185(3):955-63. doi: 10.1016/j.juro.2010.10.048. Epub 2011 Jan 19.
We investigate the association of different measures of adiposity (waist circumference, hip circumference, waist-to-hip ratio and body mass index) with overactive bladder (urinary frequency and urgency), whether the association varies by gender or age and whether it persists when models are adjusted for other confounders.
Data were from the Boston Area Community Health epidemiological survey, a random sample of 5,503 Boston, Massachusetts, residents 30 to 79 years old with equal representation from 3 racial/ethnic groups (black, Hispanic and white). Statistical analysis involved nonparametric loess models and multivariate logistic regression.
We noted distinct patterns by gender for the association of various adiposity measures with overactive bladder. Waist-to-hip ratio was not significantly associated with overactive bladder in either gender. In women the prevalence of overactive bladder increased as waist (OR adjusted for other confounders 1.10/10 cm increase) or hip circumference (OR 1.12/10 cm increase) or body mass index (OR 1.03/kg/m2 increase) increased. In men the prevalence of overactive bladder decreased as adiposity increased (OR 0.65/10 cm increase in waist circumference, OR 0.71/10 cm increase in hip circumference and OR 0.87/kg/m2 in body mass index) but only to a certain point (waist circumference 100 cm, hip circumference 115 cm and body mass index 27.5 kg/m2, respectively). At that point the prevalence of overactive bladder increased with increasing adiposity (OR 1.19/10 cm increase in waist circumference, OR 1.16/10 cm increase in hip circumference and OR 1.08/kg/m2 in body mass index).
The relationship between adiposity and overactive bladder varies by gender.
我们研究了不同肥胖指标（腰围、臀围、腰臀比和体重指数）与膀胱过度活动症（排尿频率和尿急）的关联，以及这种关联是否因性别或年龄而异，以及在调整其他混杂因素后模型是否仍然存在。
数据来自波士顿地区社区健康流行病学调查，这是一项对马萨诸塞州波士顿市 30 至 79 岁的 5503 名随机抽样居民（来自 3 个种族/族裔群体的代表人数相等，即黑种人、西班牙裔和白种人）进行的调查。统计分析涉及非参数局部加权回归模型和多变量逻辑回归。
我们注意到，不同的肥胖指标与膀胱过度活动症的关联在性别上存在明显的差异。腰臀比在男女两性中均与膀胱过度活动症无显著相关性。在女性中，随着腰围（调整其他混杂因素后的比值比为每增加 10 厘米 1.10）或臀围（每增加 10 厘米 1.12）或体重指数（每增加 1 公斤/平方米 1.03）的增加，膀胱过度活动症的患病率增加。在男性中，随着肥胖程度的增加，膀胱过度活动症的患病率下降（腰围每增加 10 厘米，比值比为 0.65；臀围每增加 10 厘米，比值比为 0.71；体重指数每增加 1 公斤/平方米，比值比为 0.87），但只在一定程度上（腰围 100 厘米，臀围 115 厘米，体重指数 27.5 公斤/平方米）。在这一点上，随着肥胖程度的增加，膀胱过度活动症的患病率增加（腰围每增加 10 厘米，比值比为 1.19；臀围每增加 10 厘米，比值比为 1.16；体重指数每增加 1 公斤/平方米，比值比为 1.08）。
肥胖与膀胱过度活动症之间的关系因性别而异。
