Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
Lab Chip. 2011 Mar 7;11(5):950-6. doi: 10.1039/c0lc00534g. Epub 2011 Jan 24.
Driven by scientific progress and economic stimulus, medical diagnostics will move to a stage in which straightforward medical diagnoses are independent of physician visits and large centralized laboratories. The future of basic diagnostic medicine will lie in the hands of private individuals. We have taken significant strides towards achieving this goal by developing an autoassembly assay for disease biomarker detection which obviates the need for washing steps and is run on a handheld sensing platform. By coupling magnetic nanotechnology with an array of magnetically responsive nanosensors, we demonstrate a rapid, multiplex immunoassay that eliminates the need for trained technicians to run molecular diagnostic tests. Furthermore, the platform is battery-powered and ultraportable, allowing the assay to be run anywhere in the world by any individual.
在科学进步和经济刺激的推动下,医学诊断将进入一个无需医生就诊和大型中央实验室即可进行简单医学诊断的阶段。基础诊断医学的未来将掌握在私人手中。我们通过开发一种用于疾病生物标志物检测的自动组装分析方法,朝着这一目标迈出了重要的一步,该方法省去了洗涤步骤,可以在手持式感应平台上运行。通过将磁纳米技术与一系列对磁响应的纳米传感器相结合,我们展示了一种快速、多重免疫分析方法,无需经过培训的技术人员即可进行分子诊断测试。此外,该平台由电池供电且超便携,允许任何人均可在世界任何地方进行检测。