Department of Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Virology. 2011 Mar 15;411(2):362-73. doi: 10.1016/j.virol.2010.12.045. Epub 2011 Feb 2.
The complement system functions as an immune surveillance system that rapidly responds to infection. Activation of the complement system by specific recognition pathways triggers a protease cascade, generating cleavage products that function to eliminate pathogens, regulate inflammatory responses, and shape adaptive immune responses. However, when dysregulated, these powerful functions can become destructive and the complement system has been implicated as a pathogenic effector in numerous diseases, including infectious diseases. This review highlights recent discoveries that have identified critical roles for the complement system in the pathogenesis of viral infection.
补体系统作为一种免疫监视系统，可快速应对感染。特定识别途径激活补体系统会触发蛋白酶级联反应，生成具有消除病原体、调节炎症反应和塑造适应性免疫反应功能的裂解产物。然而，当失调时，这些强大的功能可能会具有破坏性，补体系统已被认为是许多疾病（包括传染病）发病机制中的致病效应因子。本综述强调了最近的发现，这些发现确定了补体系统在病毒感染发病机制中的关键作用。
