Department of Clinical Social Medicine, Occupational and Environmental Dermatology and Health Services Research, University Hospital Heidelberg, University of Heidelberg, Thibautstrasse 3, 69115, Heidelberg, Germany.
Qual Life Res. 2011 Oct;20(8):1295-305. doi: 10.1007/s11136-011-9868-9. Epub 2011 Feb 24.
Several studies have looked at the relationship between childhood atopic disease and health-related quality of life (HRQoL), but existing research is limited by selected populations, small samples or lack to consider each of the three atopic conditions simultaneously.
Impact of 4-week and 12-month occurrences of the three conditions on HRQoL were analysed by the use of complex sample general linear models alone and adjusted for the other atopic conditions, sociodemographics and mental health in a population-based sample (n = 6,518) of children and adolescents aged 11-17.
In univariate analyses, total HRQoL was significantly impacted by eczema and hay fever but not asthma with stronger effects for 4-week occurrence. In multivariate analyses, 12-month occurrence of hay fever and 4-week occurrence of eczema and hay fever significantly impacted on total HRQoL. Although most of the variance in HRQoL was explained by mental health, independent effects of the atopic conditions remained.
Atopic conditions impact HRQoL over and above mental health. When analysing the relationship between atopic conditions and HRQoL, it is important to consider more immediate versus less immediate effects of the conditions. Extent of impairment and the domains affected appear to vary when different time intervals are used.
已有多项研究探讨了儿童特应性疾病与健康相关生活质量（HRQoL）之间的关系，但现有研究受到特定人群、小样本或缺乏同时考虑三种特应性疾病的限制。
本研究采用复杂样本广义线性模型，对基于人群的 11-17 岁儿童和青少年样本（n=6518）中三种疾病在 4 周和 12 个月的发生情况对 HRQoL 的影响进行了分析，并对其他特应性疾病、社会人口统计学和心理健康因素进行了调整。
在单变量分析中，湿疹和花粉热对总 HRQoL 有显著影响，但哮喘无显著影响，4 周时的影响更强。在多变量分析中，花粉热的 12 个月发生和湿疹及花粉热的 4 周发生对总 HRQoL 有显著影响。尽管心理健康对 HRQoL 的解释程度最大，但特应性疾病的独立影响仍然存在。
特应性疾病对 HRQoL 的影响超出了心理健康的影响。在分析特应性疾病与 HRQoL 之间的关系时，考虑疾病的即时和非即时影响非常重要。当使用不同的时间间隔时，损害的程度和受影响的领域似乎有所不同。
