Institute of Translational Pharmacology (IFT), National Council of Research, Rome, Via Fosso del Cavaliere 100, 00173, Rome, Italy.
Inflammation. 2012 Feb;35(1):240-8. doi: 10.1007/s10753-011-9310-z.
Interleukin-17 (IL-17) is a proinflammatory cytokine produced, although not exclusively, by T helper 17 recently identified as a distinct T helper lineage mediating tissue inflammation. IL-17 is known to be involved in a number of chronic disorders although the mechanisms regulating its production in inflammatory disease are still unclear. The beneficial properties of the polyphenolic compound resveratrol including its anti-inflammatory, antioxidant, and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases are well-known. In addition, derivatives of resveratrol, including glucosylated molecules as polydatin have been linked to similar beneficial effects. We have investigated the effects of resveratrol and polydatin on the in vitro production of IL-17 in a model of inflammation in vitro. The results obtained by activated human peripheral blood mononuclear cells, stimulated with anti-CD3/anti-CD28 monoclonal antibodies and treated with these polyphenolic compounds at different concentrations show that both decrease IL-17 production in a concentration-dependent manner. This study confirms the anti-inflammatory activity of resveratrol and its derivatives and suggests a potential clinical relevance in the therapy of inflammatory diseases.
白细胞介素-17 (IL-17) 是一种前炎性细胞因子，尽管不是唯一的，由辅助性 T 细胞 17 最近被确定为一种独特的辅助性 T 细胞谱系，介导组织炎症。已知白细胞介素-17 参与了许多慢性疾病，尽管调节其在炎症性疾病中产生的机制仍不清楚。白藜芦醇等多酚化合物具有抗炎、抗氧化和抗肿瘤作用，其在衰老过程中的作用以及预防心脏病和神经退行性疾病的作用是众所周知的。此外，白藜芦醇的衍生物，包括葡糖苷化分子如白藜芦醇苷，也与类似的有益作用有关。我们研究了白藜芦醇和白藜芦醇苷在体外炎症模型中体外产生白细胞介素-17 的影响。用抗 CD3/抗 CD28 单克隆抗体刺激激活的人外周血单核细胞，并在不同浓度下用这些多酚化合物处理，得到的结果表明，这两种化合物都以浓度依赖性方式降低白细胞介素-17 的产生。这项研究证实了白藜芦醇及其衍生物的抗炎活性，并表明其在炎症性疾病治疗中具有潜在的临床相关性。
