Department of Pediatric Pulmonology and Pediatric Allergy, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Clin Exp Allergy. 2011 Apr;41(4):574-81. doi: 10.1111/j.1365-2222.2011.03711.x.
Food-allergic reactions occur in 3-4% of the adult population in Western countries. It has been shown that food allergy may impair health-related quality of life (HRQL). Food allergy quality of life questionnaires (FAQLQs) have been developed and validated, including an adult form (FAQLQ-AF). These questionnaires may be particularly useful for cross-cultural comparisons.
The aims of this study were to translate the FAQLQ-AF from Dutch into English and validate an online version in the United States. Additionally, HRQL of American and Dutch food-allergic adults was compared.
The Dutch FAQLQ-AF was translated into English as set out by the World Health Organization and converted to an electronic online format. Participants (food allergic American adults) were recruited through the 'Food Allergy and Anaphylaxis Network' website and completed the questionnaire online. Construct validity, internal consistency, discriminative ability and feasibility were analysed. A cross-cultural comparison was made using the Dutch FAQLQ-AF scores.
Data from 180 American participants were analysed. The online FAQLQ-AF had a good construct validity (correlation with FAIM: ρ=0.72; P<0.001), internal consistency (Cronbach's α=0.95) and was discriminative for 'anaphylaxis' vs. 'no anaphylaxis' and 'number of food allergies'. The most striking finding was a significantly greater impairment in HRQL in the American participants, as compared with their Dutch counterparts (the total FAQLQ-AF scores were 4.3 vs. 3.5, respectively; P<0.001, where 1 signifies no impairment and 7 signifies extreme impairment in HRQL).
The online American FAQLQ-AF is a valid instrument to measure HRQL in food-allergic patients in the United States. Additionally, HRQL of American food-allergic adults may be more impaired than Dutch food-allergic adults. The FAQLQ-AF can now be used to determine the HRQL in American food-allergic adults and can assist clinicians in optimizing management strategies for food-allergic patients.
在西方国家，3-4%的成年人有食物过敏反应。研究表明，食物过敏会影响健康相关生活质量（HRQL）。已经开发并验证了食物过敏生活质量问卷（FAQLQ），包括成人形式（FAQLQ-AF）。这些问卷对于跨文化比较可能特别有用。
本研究旨在将 FAQLQ-AF 从荷兰语翻译成英语，并在美国验证其在线版本。此外，比较了美国和荷兰食物过敏的成年人的 HRQL。
按照世界卫生组织的规定，将荷兰语 FAQLQ-AF 翻译成英语，并将其转换为在线电子格式。通过“食物过敏和过敏反应网络”网站招募参与者（美国食物过敏成年人），并在线完成问卷。分析了结构有效性、内部一致性、区分能力和可行性。使用荷兰语 FAQLQ-AF 评分进行了跨文化比较。
分析了 180 名美国参与者的数据。在线 FAQLQ-AF 具有良好的结构有效性（与 FAIM 的相关性：ρ=0.72；P<0.001），内部一致性（Cronbach's α=0.95），并且对“过敏反应”与“无过敏反应”和“食物过敏数量”具有区分能力。最引人注目的发现是，与荷兰人相比，美国人的 HRQL 明显受损（总 FAQLQ-AF 评分分别为 4.3 和 3.5；P<0.001，其中 1 表示 HRQL 无损害，7 表示 HRQL 严重受损）。
在线美国 FAQLQ-AF 是一种有效测量美国食物过敏患者 HRQL 的工具。此外，美国食物过敏成年人的 HRQL 可能比荷兰食物过敏成年人更受损。FAQLQ-AF 现在可用于确定美国食物过敏成年人的 HRQL，并帮助临床医生优化食物过敏患者的管理策略。
