Georgia State University, Atlanta, GA 30333, USA.
J Autism Dev Disord. 2012 Feb;42(2):191-200. doi: 10.1007/s10803-011-1230-0.
We examined whether clinically distinct subgroups can be derived from a sample of toddlers (n = 186) who failed the Modified Checklist for Autism in Toddlers, received a comprehensive clinical evaluation, and were diagnosed with an autism spectrum disorder (ASD). Three subgroups emerged from cluster analysis distinguished by (a) social, communication, and intellectual skills and (b) the rate and intensity of repetitive behaviors and abnormal sensory response. Preoccupations, compulsions, and rituals did not distinguish resultant subgroups. These results support a dimensional diagnostic view of ASDs in toddlers since subgroup differences were based on symptom severity rather than different symptom profiles. Results also identify specific types and levels of behavioral deficit relevant to toddler populations. Implications for early diagnosis are discussed.
我们研究了从一组未能通过婴幼儿自闭症检查表修订版(n=186)的幼儿样本中是否可以衍生出临床特征不同的亚组。这些幼儿接受了全面的临床评估,并被诊断为自闭症谱系障碍(ASD)。聚类分析得出了三个亚组,这些亚组在社交、沟通和智力技能方面存在差异,同时在重复行为和异常感觉反应的频率和强度方面也存在差异。占据、强迫和仪式行为并不能区分这些亚组。这些结果支持了幼儿 ASD 的维度诊断观点,因为亚组差异是基于症状严重程度而不是不同的症状特征。结果还确定了与幼儿群体相关的特定类型和程度的行为缺陷。讨论了对早期诊断的影响。