Kennedy Brendan F, Liang Xing, Adie Steven G, Gerstmann Derek K, Quirk Bryden C, Boppart Stephen A, Sampson David D
Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, Crawley, Western Australia, Australia.
Opt Express. 2011 Mar 28;19(7):6623-34. doi: 10.1364/OE.19.006623.
We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case.
我们展示了使用光学相干弹性成像（OCE）记录的首批三维（3D）数据集。使用光谱域光学相干断层扫描（OCT）系统在人体皮肤活体上测量单轴应变率，该系统提供的线速率比先前报道的活体OCE成像高450倍以上。使用环形致动器样品臂以125Hz的频率施加机械激励，这在OCE测量中首次采用了受控的静态预载。我们对正常和水合皮肤进行了二维处理并三维显示的三维OCE，观察到在水合情况下角质层有更具弹性的反应。
