不同动物物种及人类消化道的定植抗力：一项比较研究。
The colonization resistance of the digestive tract in different animal species and in man; a comparative study.
作者信息
Van der Waaij D, Van der Waaij B D
机构信息
Laboratory for Medical Microbiology, University of Groningen, The Netherlands.
出版信息
Epidemiol Infect. 1990 Oct;105(2):237-43. doi: 10.1017/s0950268800047841.
The present study has attempted to determine the colonization resistance (CR) of the digestive tract by biotyping Enterobacteriaceae in four faecal samples per subject of five different animal species as well as man. The results indicate that the degree of bacterial contamination with Enterobacteriaceae from the environment may strongly influence the outcome. Both conventionally living chicken and man, showed a much wider range of the 'confidence limits of the mean' of the mean number of biotypes per faecal sample between individual subjects, than was found between subjects maintained under laboratory circumstances. Yet there appeared a statistically significant difference in CR between some of the animal species as a group. Man did not differ from monkeys, however, both differed from the rodents species studied. Monkeys differed also from dogs and the latter from rodents. It is concluded that the CR measured by determining the mean number of biotypes of Enterobacteriaceae can only be used for accurate comparison of the CR between subjects, if the 'bacteriological environment' is known; i.e. the sources of contamination.
本研究试图通过对五种不同动物物种以及人类的每个受试者的四份粪便样本中的肠杆菌科进行生物分型，来确定消化道的定植抗力（CR）。结果表明，环境中肠杆菌科的细菌污染程度可能会强烈影响结果。与在实验室环境下饲养的受试者相比，传统饲养的鸡和人类个体之间每个粪便样本的生物型平均数的“均值置信限”范围要宽得多。然而，作为一个群体的一些动物物种之间的CR在统计学上存在显著差异。人类与猴子没有差异，但是两者都与所研究的啮齿动物物种不同。猴子也与狗不同，而狗与啮齿动物不同。得出的结论是，如果已知“细菌学环境”，即污染源，那么通过测定肠杆菌科生物型平均数来测量的CR只能用于准确比较受试者之间的CR。
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