Sarov I, Larsen A M, Heron I, Andersen H K
Med Microbiol Immunol. 1978 Nov 17;166(1-4):81-9. doi: 10.1007/BF02121137.
Lymphocytes from healthy adult individuals were examined for their ability to incorporate thymidine in the presence of cytomegalovirus (CMV) and dense bodies. It was found that lymphocytes from donors with antibodies to CMV were stimulated to incorporate thymidine-14C both by preparation of CMV and CMV dense bodies. Lymphocytes from CMV seronegative donors did not respond. Dilution experiments and the dose-response curve indicate that the stimulation induced by the dense body preparation was not caused by the small amounts of contaminating CMV particles. These results indicate that in healthy human adults there is a correlation between CMV seropositivity and in vitro lymphocyte transformation, induced by either CMV or by dense bodies.
对来自健康成年个体的淋巴细胞进行检测，观察其在巨细胞病毒（CMV）和致密体存在的情况下掺入胸苷的能力。结果发现，来自具有CMV抗体供体的淋巴细胞，在CMV制剂和CMV致密体的作用下，均被刺激掺入14C-胸苷。来自CMV血清阴性供体的淋巴细胞则无反应。稀释实验和剂量反应曲线表明，致密体制剂诱导的刺激并非由少量污染的CMV颗粒所致。这些结果表明，在健康成年人体内，CMV血清阳性与由CMV或致密体诱导的体外淋巴细胞转化之间存在相关性。
