来自帕劳环礁蓝藻组合的杀软体动物代谢产物。
Molluscicidal metabolites from an assemblage of Palmyra Atoll cyanobacteria.
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
出版信息
J Nat Prod. 2011 May 27;74(5):1175-81. doi: 10.1021/np200106b. Epub 2011 Apr 7.
Abstract
Molluscicides can play an important role in the control of schistosomiasis because snails of the genus Biomphalaria act as intermediate hosts for the parasite. Schistosomiasis is one of 13 neglected tropical diseases with high morbidity and mortality that collectively affect one billion of the world's poorest population, mainly in developing countries. Thiopalmyrone (1) and palmyrrolinone (2), metabolites isolated from extracts of a Palmyra Atoll environmental assemblage of two cyanobacteria, cf. Oscillatoria and Hormoscilla spp., represent new and potent molluscicidal chemotypes against Biomphalaria glabrata (LC50=8.3 and 6.0 μM, respectively). A slight enhancement in molluscicidal effect (LC50=5.0 μM) was observed when these two natural products were utilized as an equimolar binary mixture.
摘要
杀螺剂在血吸虫病防治中可发挥重要作用，因为双腔吸虫属蜗牛是寄生虫的中间宿主。血吸虫病是 13 种被忽视的热带病之一，具有高发病率和死亡率，主要影响世界上最贫困的 10 亿人口，这些国家主要在发展中国家。硫Palmyr 酮（1）和 palmyrrolinone（2），是从两个蓝藻 cf. Oscillatoria 和 Hormoscilla spp. 的 Palmyra 环礁环境组合提取物中分离得到的代谢物，对光滑双脐螺（LC50 分别为 8.3 和 6.0 μM）具有新型强效杀螺活性。当这两种天然产物用作等摩尔二元混合物时，观察到杀螺效果略有增强（LC50=5.0 μM）。
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