Yogo Y, Kitamura T, Sugimoto C, Ueki T, Aso Y, Hara K, Taguchi F
Department of Viral Infection, University of Tokyo, Japan.
J Virol. 1990 Jun;64(6):3139-43. doi: 10.1128/JVI.64.6.3139-3143.1990.
We molecularly cloned JC polyomavirus DNAs from urine samples of eight nonimmunosuppressed patients and two healthy individuals. The cloned viral DNAs all contained an archetypal regulatory sequence from which various regulatory sequences of JC polyomavirus isolates derived from patients with progressive multifocal leukoencephalopathy could have evolved by deletion and amplification.
我们从8名非免疫抑制患者和2名健康个体的尿液样本中分子克隆了JC多瘤病毒DNA。克隆的病毒DNA均包含一个原型调控序列，进行性多灶性白质脑病患者来源的JC多瘤病毒分离株的各种调控序列可能是通过该序列的缺失和扩增而进化而来的。
