Department of Pharmacology, K.L.E. University's College of Pharmacy, II Block, Rajaji Nagar, Bangalore - 560 010, Karnataka, India.
Indian J Pharmacol. 2010 Dec;42(6):380-3. doi: 10.4103/0253-7613.71925.
To evaluate the potential of Mimusops elengi in the treatment of renal calculi.
Petroleum ether, chloroform, and alcohol extracts of Mimusops elengi bark were evaluated for antiurolithiatic and antioxidant activity in male albino Wistar rats. Ethylene glycol (0.75%) in drinking water was fed to all the groups (Groups II-IX) except normal control (Group I) for 28 days to induce urolithiasis for curative (CR) and preventive (PR) regimen. Groups IV, V, and VI served as CR, and groups VII, VIII, and IX as PR were treated with different extracts of M. elengi bark. Groups I, II, and III served as normal control, positive control (hyperurolithiatic), and standard (cystone 750 mg/kg), respectively. Oxalate, calcium, and phosphate were monitored in the urine and kidney. Serum BUN, creatinine, and uric acid were also recorded. In vivo antioxidant parameters such as lipid peroxidation (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were also monitored.
All the extracts of M. elengi were safe orally and exhibited no gross behavioral changes in the rats. In hypercalculi animals, the oxalate, calcium, and phosphate excretion grossly increased. However, the increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly (P < 0.001) lowered by curative and preventive treatment with alcohol extract (AlE) of M. elengi. It was also observed that alcoholic extract of M. elengi produced significant (P < 0.001) decrease in MDA, and increased GSH, SOD, and CAT. These results confirm that AlE of M. elengi possess potent antiurolithiatic activity.
The results obtained suggest potential usefulness of the AlE of M. elengi bark as an antiurolithiatic agent.
评估无忧树在治疗肾结石中的潜力。
评估无忧树树皮的石油醚、氯仿和醇提取物对雄性白化 Wistar 大鼠的抗结石和抗氧化活性。除正常对照组（第 I 组）外，所有组（第 II 组至第 IX 组）均给予饮用水中的乙二醇（0.75%），以诱导结石形成，进行治疗（CR）和预防（PR）方案。第 IV、V 和 VI 组作为 CR，第 VII、VIII 和 IX 组作为 PR，用无忧树树皮的不同提取物进行治疗。第 I、II 和 III 组分别作为正常对照组、阳性对照组（高尿石症）和标准组（结石素 750mg/kg）。监测尿液和肾脏中的草酸盐、钙和磷酸盐。还记录血清 BUN、肌酐和尿酸。还监测体内抗氧化参数，如脂质过氧化（MDA）、谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）。
无忧树的所有提取物口服均安全，对大鼠无明显的行为变化。在高结石动物中，草酸盐、钙和磷酸盐的排泄量明显增加。然而，用无忧树的醇提取物进行治疗和预防治疗可显著（P<0.001）降低结石形成成分在结石形成大鼠肾脏中的沉积。还观察到，无忧树的醇提取物可显著（P<0.001）降低 MDA，并增加 GSH、SOD 和 CAT。这些结果证实，无忧树的醇提取物具有潜在的抗结石活性。
研究结果表明，无忧树树皮的醇提取物可能具有作为抗结石剂的潜在用途。
