TIFAC CORE in Green Pharmacy, B. R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India.
Indian J Pharmacol. 2011 Jul;43(4):466-8. doi: 10.4103/0253-7613.83124.
This study was aimed to evaluate the effectiveness of the Unex capsule on albino rats as a preventive agent against the development of kidney stones. The Unex capsule is a marketed product of Unijules Life Sciences, Nagpur, containing the extracts of Boerhaavia diffusa and Tribulus terrestris. Activity of Unex was studied using the ethylene glycol-induced urolithiasis model. Standard drug used was Cystone. Several parameters were used including urinary volume, urine pH, urine analysis, and serum analysis to assess the activity. The results indicated that the administration of Unex to rats with ethylene glycol-induced lithiasis significantly reduced and prevented the growth of urinary stones (P < 0.01). Also, the treatment of lithiasis-induced rats by Unex restored all the elevated biochemical parameters (creatinine, uric acid, and blood urea nitrogen), restored the urine pH to normal, and increased the urine volume significantly (P < 0.01) when compared to the model control drug. This study supports the usage of Unex in urolithiasis and the utility could further be confirmed in other animal models.
本研究旨在评估 Unex 胶囊对白化病大鼠作为肾结石预防剂的有效性。Unex 胶囊是 Unijules 生命科学公司（位于那格浦尔）的市售产品，含有白花丹和蒺藜的提取物。使用乙二醇诱导的尿石症模型研究了 Unex 的活性。使用的标准药物是 Cystone。使用包括尿体积、尿 pH 值、尿液分析和血清分析在内的多个参数来评估活性。结果表明，Unex 给药可显著减少并预防乙二醇诱导结石大鼠的肾结石生长（P<0.01）。此外，与模型对照药物相比，Unex 治疗结石诱导大鼠可恢复所有升高的生化参数（肌酐、尿酸和血尿素氮），将尿 pH 值恢复正常，并显著增加尿体积（P<0.01）。这项研究支持在尿石症中使用 Unex，其用途可以在其他动物模型中进一步证实。
