Blok D, von Ogtrop M, Arndt J W, Camps J A, Feitsma R I, Goedemans W, Pauwels E K
Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
Eur J Nucl Med. 1990;16(4-6):303-5. doi: 10.1007/BF00842784.
Previous reports on the use of radiolabelled immunoglobulins led us to undertake a pilot experiment in an animal model to investigate the potentials of Tc 99m-immunoglobulin scintigraphy in the detection of infectious foci. Mice infected in one leg with staphylococcus infection were injected with Tc 99m-immunoglobulin, Tc 99m-albumin or gallium citrate Ga 67. The results obtained by scintigraphy suggested a specific accumulation of radiolabelled immunoglobulin at the site of infection. Visualization of the infection and the image quality, especially the 6- and 24-h images, were clearly enhanced after the use of immunoglobulin preparations as compared with gallium.
先前有关使用放射性标记免疫球蛋白的报道促使我们在动物模型中进行一项试点实验，以研究锝99m免疫球蛋白闪烁扫描术在检测感染灶方面的潜力。将一侧腿部感染葡萄球菌的小鼠注射锝99m免疫球蛋白、锝99m白蛋白或枸橼酸镓Ga 67。闪烁扫描术获得的结果表明放射性标记免疫球蛋白在感染部位有特异性聚集。与镓相比，使用免疫球蛋白制剂后，感染的可视化以及图像质量，尤其是6小时和24小时图像，均明显增强。
