Eggers H J
Institut für Virologie, Universität zu Köln.
Zentralbl Bakteriol. 1990 May;273(1):36-51. doi: 10.1016/s0934-8840(11)80238-0.
Various members of the picornavirus family, adenovirus 2, papovavirus SV40, as well as rotaviruses were tested for inactivation of infectivity by hand disinfectants formulated on the basis of ethanol. The inactivating effect of povidine-iodine (Betaisodona) on enteroviruses and rotaviruses was also investigated. The degree of inactivation by these disinfectants on the various non-enveloped viruses studied, however, was found unpredictable. In fact, striking differences with the very same disinfectant existed even for members of one virus family. Isopropanol was inactive against enteroviruses. These findings are discussed from a theoretical point of view and practical implications are considered. Disinfection of poliovirus 1-contaminated hands by 80% (v/v) ethanol proved not very effective, despite encouraging results obtained in the suspension test. The load of rotavirus-contaminated hands, however, was substantially reduced by treatment with Desderman. A practical regimen can be proposed.
对肠道病毒科的各种病毒成员、腺病毒2型、乳头多瘤空泡病毒SV40以及轮状病毒进行了测试，以检测基于乙醇配制的手部消毒剂对其传染性的灭活效果。还研究了聚维酮碘（贝泰索罗）对肠道病毒和轮状病毒的灭活作用。然而，发现这些消毒剂对所研究的各种无包膜病毒的灭活程度无法预测。事实上，即使对于同一病毒家族的成员，使用同一种消毒剂也存在显著差异。异丙醇对肠道病毒无灭活作用。从理论角度对这些发现进行了讨论，并考虑了实际意义。尽管在悬液试验中取得了令人鼓舞的结果，但80%（v/v）乙醇对受脊髓灰质炎病毒1污染的手部进行消毒的效果并不理想。然而，使用德施曼进行处理后，受轮状病毒污染的手部病毒载量大幅降低。可以提出一个实际的方案。
