一种乙醇含量降低的新型手部消毒剂的杀病毒活性：与其他酒精基制剂的比较。
Virucidal activity of a new hand disinfectant with reduced ethanol content: comparison with other alcohol-based formulations.
作者信息
Kramer A, Galabov A S, Sattar S A, Döhner L, Pivert A, Payan C, Wolff M H, Yilmaz A, Steinmann J
机构信息
Institute of Hygiene and Environmental Medicine, Ernst Moritz Arndt University Greifswald, Walther Rathenau Str. 49a, 17489 Greifswald, Germany.
出版信息
J Hosp Infect. 2006 Jan;62(1):98-106. doi: 10.1016/j.jhin.2005.06.020. Epub 2005 Nov 22.
A new formula with reduced ethanol content (55%) in combination with 10% propan-1-ol, 5.9% propan-1.2-diol, 5.7% butan-1.3-diol and 0.7% phosphoric acid exhibited a broad spectrum of virucidal activity. In quantitative suspension tests, with and without protein load, this formulation reduced the infectivity titre of seven enveloped (influenza A and B, herpes simplex 1 and 2, bovine corona, respiratory syncytial, vaccinia, hepatitis B, bovine viral diarrhoea) and four non-enveloped (hepatitis A, polio, rota, feline calici) viruses >10(3)-fold within 30s. In comparative testing, only 95% ethanol showed similar levels of activity. In fingerpad tests, the formulation produced a log10 reduction factor of the titre of poliovirus type 1 (Sabin) of 3.04 in 30s compared with 1.32 by 60% propan-2-ol. Testing against feline calicivirus produced a log10 reduction factor of 2.38 by the test formulation; in contrast, the log10 reduction factors with 70% ethanol and 70% propan-1-ol were 0.68 and 0.70, respectively.
一种乙醇含量降低（55%）并与10%丙醇、5.9% 1,2 - 丙二醇、5.7% 1,3 - 丁二醇和0.7%磷酸混合的新配方展现出了广泛的杀病毒活性。在有和没有蛋白质负载的定量悬浮试验中，该配方在30秒内将七种包膜病毒（甲型和乙型流感病毒、单纯疱疹病毒1型和2型、牛冠状病毒、呼吸道合胞病毒、痘苗病毒、乙型肝炎病毒、牛病毒性腹泻病毒）和四种非包膜病毒（甲型肝炎病毒、脊髓灰质炎病毒、轮状病毒、猫杯状病毒）的感染性滴度降低了10³倍以上。在对比测试中，只有95%乙醇表现出了相似的活性水平。在指垫试验中，与60%异丙醇在30秒内使脊髓灰质炎病毒1型（萨宾株）滴度的对数减少因子为1.32相比，该配方在30秒内产生的对数减少因子为3.04。针对猫杯状病毒进行测试时，测试配方产生的对数减少因子为2.38；相比之下，70%乙醇和70%丙醇的对数减少因子分别为0.68和0.70。
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