• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

杆状病毒：关于其多样性和保守性的分子见解

Baculovirus: molecular insights on their diversity and conservation.

作者信息

Miele Solange Ana Belen, Garavaglia Matías Javier, Belaich Mariano Nicolás, Ghiringhelli Pablo Daniel

机构信息

LIGBCM (Laboratorio de Ingeniería Genética y Biología Celular y Molecular), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 352, Bernal, Argentina.

出版信息

Int J Evol Biol. 2011;2011:379424. doi: 10.4061/2011/379424. Epub 2011 Apr 11.

DOI:10.4061/2011/379424
PMID:21716740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3119482/
Abstract

The Baculoviridae is a large group of insect viruses containing circular double-stranded DNA genomes of 80 to 180 kbp. In this study, genome sequences from 57 baculoviruses were analyzed to reevaluate the number and identity of core genes and to understand the distribution of the remaining coding sequences. Thirty one core genes with orthologs in all genomes were identified along with other 895 genes differing in their degrees of representation among reported genomes. Many of these latter genes are common to well-defined lineages, whereas others are unique to one or a few of the viruses. Phylogenetic analyses based on core gene sequences and the gene composition of the genomes supported the current division of the Baculoviridae into 4 genera: Alphabaculovirus, Betabaculovirus, Gammabaculovirus, and Deltabaculovirus.

摘要

杆状病毒科是一大类昆虫病毒，其基因组为环状双链DNA，大小在80至180千碱基对之间。在本研究中，分析了57种杆状病毒的基因组序列，以重新评估核心基因的数量和同一性，并了解其余编码序列的分布情况。确定了31个在所有基因组中都有直系同源物的核心基因，以及其他895个基因，这些基因在已报道的基因组中的代表性程度各不相同。这些后一类基因中的许多在明确的谱系中是常见的，而其他一些则是一种或几种病毒所特有的。基于核心基因序列和基因组的基因组成的系统发育分析支持了目前将杆状病毒科分为4个属的分类：甲型杆状病毒属、乙型杆状病毒属、丙型杆状病毒属和丁型杆状病毒属。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/aadbd84f17c2/IJEB2011-379424.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/054a1c0dd9bc/IJEB2011-379424.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/6cd209d85a91/IJEB2011-379424.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/99345496ad77/IJEB2011-379424.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/22a8b8f207ab/IJEB2011-379424.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/aadbd84f17c2/IJEB2011-379424.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/054a1c0dd9bc/IJEB2011-379424.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/6cd209d85a91/IJEB2011-379424.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/99345496ad77/IJEB2011-379424.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/22a8b8f207ab/IJEB2011-379424.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ef9/3119482/aadbd84f17c2/IJEB2011-379424.005.jpg

相似文献

1
Baculovirus: molecular insights on their diversity and conservation.杆状病毒：关于其多样性和保守性的分子见解
Int J Evol Biol. 2011;2011:379424. doi: 10.4061/2011/379424. Epub 2011 Apr 11.
2
On the classification and nomenclature of baculoviruses: a proposal for revision.关于杆状病毒的分类和命名：修订提案
Arch Virol. 2006 Jul;151(7):1257-66. doi: 10.1007/s00705-006-0763-6. Epub 2006 May 2.
3
Codon usage in Alphabaculovirus and Betabaculovirus hosted by the same insect species is weak, selection dominated and exhibits no more similar patterns than expected.由同一昆虫物种宿主的甲型杆状病毒和乙型杆状病毒中的密码子使用情况较弱，受选择主导，且没有表现出比预期更相似的模式。
Infect Genet Evol. 2016 Oct;44:412-417. doi: 10.1016/j.meegid.2016.07.042. Epub 2016 Jul 30.
4
The ac53, ac78, ac101, and ac103 genes are newly discovered core genes in the family Baculoviridae.ac53、ac78、ac101 和 ac103 基因是新发现的杆状病毒科核心基因。
J Virol. 2012 Nov;86(22):12069-79. doi: 10.1128/JVI.01873-12. Epub 2012 Aug 29.
5
The Complete Genome of a New Betabaculovirus from Clostera anastomosis.来自柳毒蛾的一种新型β杆状病毒的全基因组
PLoS One. 2015 Jul 13;10(7):e0132792. doi: 10.1371/journal.pone.0132792. eCollection 2015.
6
A Novel Betabaculovirus Isolated from the Monocot Pest Mocis latipes (Lepidoptera: Noctuidae) and the Evolution of Multiple-Copy Genes.一种从单子叶害虫夜蛾科（鳞翅目）的 Mocis latipes 中分离出的新型杆状病毒及其多拷贝基因的进化
Viruses. 2018 Mar 16;10(3):134. doi: 10.3390/v10030134.
7
Protein-Gene Orthology in : An Exhaustive Analysis to Redefine the Ancestrally Common Coding Sequences.在 中蛋白-基因直系同源物：对祖先共同编码序列的详尽分析，以重新定义之。
Viruses. 2023 Apr 29;15(5):1091. doi: 10.3390/v15051091.
8
Baculovirus genomics.杆状病毒基因组学。
Curr Drug Targets. 2007 Oct;8(10):1051-68. doi: 10.2174/138945007782151333.
9
Genome of Cnaphalocrocis medinalis Granulovirus, the First Crambidae-Infecting Betabaculovirus Isolated from Rice Leaffolder to Sequenced.稻纵卷叶螟颗粒体病毒基因组，首个从稻纵卷叶螟中分离得到并测序的夜蛾科β-杆状病毒。
PLoS One. 2016 Feb 5;11(2):e0147882. doi: 10.1371/journal.pone.0147882. eCollection 2016.
10
A betabaculovirus encoding a gp64 homolog.一种编码gp64同源物的β杆状病毒。
BMC Genomics. 2016 Feb 4;17:94. doi: 10.1186/s12864-016-2408-9.

引用本文的文献

1
CRISPR/Cas9-Driven Engineering of AcMNPV Using Dual gRNA for Optimized Recombinant Protein Production.利用双gRNA通过CRISPR/Cas9驱动对苜蓿银纹夜蛾核多角体病毒进行工程改造以优化重组蛋白生产
Viruses. 2025 Jul 25;17(8):1041. doi: 10.3390/v17081041.
2
Baculovirus Variant Detection from Transient CRISPR-Cas9-Mediated Disruption of at Different Gene Locations.从不同基因位置的瞬时CRISPR-Cas9介导的破坏中检测杆状病毒变体
Int J Mol Sci. 2025 Jun 17;26(12):5805. doi: 10.3390/ijms26125805.
3
Adapting Next-Generation Sequencing to CRISPR-Cas9 Genome Editing of Recombinant MNPV Vectors: From Shotgun to Tiled-Amplicon Sequencing.

本文引用的文献

1
Autographa californica multiple nucleopolyhedrovirus ODV-E56 is a per os infectivity factor, but is not essential for binding and fusion of occlusion-derived virus to the host midgut.美洲棉铃虫多角体病毒 ODV-E56 是一种经口感染因子，但对于结合和融合包埋型病毒与宿主中肠不是必需的。
Virology. 2011 Jan 5;409(1):69-76. doi: 10.1016/j.virol.2010.09.027.
2
Autographa californica multiple nucleopolyhedrovirus core gene ac92 (p33) is required for efficient budded virus production.美洲棉铃虫多核多角体病毒核心基因 ac92（p33）对于有丝分裂病毒的有效生产是必需的。
Virology. 2011 Jan 5;409(1):38-45. doi: 10.1016/j.virol.2010.09.023. Epub 2010 Oct 20.
3
使下一代测序适用于重组杆状病毒载体的CRISPR-Cas9基因组编辑：从鸟枪法测序到平铺扩增子测序
Viruses. 2025 Mar 18;17(3):437. doi: 10.3390/v17030437.
4
The Genome Sequences of Baculoviruses from the Tufted Apple Bud Moth, , Reveal Recombination Between an Alphabaculovirus and a Betabaculovirus from the Same Host.来自簇状苹果芽蛾的杆状病毒基因组序列揭示了同一宿主的甲型杆状病毒和乙型杆状病毒之间的重组。
Viruses. 2025 Jan 30;17(2):202. doi: 10.3390/v17020202.
5
The mortality of Bombyx mori larvae challenged by BmNPV is reduced when supplemented with Lactobacillus acidophilus bacteria.当用嗜酸乳杆菌进行补充时，受家蚕核型多角体病毒攻击的家蚕幼虫的死亡率会降低。
BMC Res Notes. 2024 Dec 17;17(1):359. doi: 10.1186/s13104-024-07019-9.
6
Sequencing, Analysis and Organization of the Complete Genome of a Novel Baculovirus Nucleopolyhedrovirus (CaabNPV).新型杆状病毒核多角体病毒（CaabNPV）全基因组的测序、分析与组织。
Viruses. 2024 Feb 4;16(2):252. doi: 10.3390/v16020252.
7
Effects of Mixed Baculovirus Infections in Biological Control: A Comprehensive Historical and Technical Analysis.混合杆状病毒感染在生物防治中的作用：全面的历史和技术分析。
Viruses. 2023 Aug 30;15(9):1838. doi: 10.3390/v15091838.
8
Protein-Gene Orthology in : An Exhaustive Analysis to Redefine the Ancestrally Common Coding Sequences.在 中蛋白-基因直系同源物：对祖先共同编码序列的详尽分析，以重新定义之。
Viruses. 2023 Apr 29;15(5):1091. doi: 10.3390/v15051091.
9
A sensitive assay for scrutiny of Autographa californica multiple nucleopolyhedrovirus genes using CRISPR-Cas9.利用 CRISPR-Cas9 技术对美洲棉铃虫多粒包埋型核型多角体病毒基因进行灵敏检测。
Appl Microbiol Biotechnol. 2023 Jul;107(13):4323-4335. doi: 10.1007/s00253-023-12462-y. Epub 2023 May 26.
10
A Renewed Appreciation of Nucleopolyhedrovirus BJ (Formerly Nucleopolyhedrovirus) with Whole Genome Sequencing.全基因组测序对 BJ 核型多角体病毒（原名：核型多角体病毒）的重新认识。
Viruses. 2022 Mar 16;14(3):618. doi: 10.3390/v14030618.
Autographa californica multiple nucleopolyhedrovirus Ac92 (ORF92, P33) is required for budded virus production and multiply enveloped occlusion-derived virus formation.
苜蓿银纹夜蛾多核型多角体病毒 Ac92（ORF92，P33）是出芽型病毒产生和多包被包埋型病毒形成所必需的。
J Virol. 2010 Dec;84(23):12351-61. doi: 10.1128/JVI.01598-10. Epub 2010 Sep 22.
4
Specificity of baculovirus P6.9 basic DNA-binding proteins and critical role of the C terminus in virion formation.杆状病毒 P6.9 碱性 DNA 结合蛋白的特异性及其 C 末端在病毒形成中的关键作用。
J Virol. 2010 Sep;84(17):8821-8. doi: 10.1128/JVI.00072-10. Epub 2010 Jun 2.
5
Comparative analysis of the genomes of Bombyx mandarina and Bombyx mori nucleopolyhedroviruses.中华虎凤蝶核型多角体病毒与家蚕核型多角体病毒基因组的比较分析。
J Microbiol. 2010 Feb;48(1):102-10. doi: 10.1007/s12275-009-0197-4. Epub 2010 Mar 11.
6
Genomic sequencing and analyses of Lymantria xylina multiple nucleopolyhedrovirus.《舞毒蛾多粒包埋型核型多角体病毒基因组测序与分析》
BMC Genomics. 2010 Feb 18;11:116. doi: 10.1186/1471-2164-11-116.
7
Identification of protein-protein interactions of the occlusion-derived virus-associated proteins of Helicoverpa armigera nucleopolyhedrovirus.鉴定棉铃虫核多角体病毒的封闭衍生病毒相关蛋白的蛋白-蛋白相互作用。
J Gen Virol. 2010 Mar;91(Pt 3):659-70. doi: 10.1099/vir.0.017103-0. Epub 2009 Nov 11.
8
Autographa californica multiple nucleopolyhedrovirus core gene ac96 encodes a per Os infectivity factor (PIF-4).苜蓿银纹夜蛾多核多角体病毒核心基因ac96编码一种经口感染因子（PIF-4）。
J Virol. 2009 Dec;83(23):12569-78. doi: 10.1128/JVI.01141-09. Epub 2009 Sep 16.
9
Evidence of a major role of GP64 in group I alphabaculovirus evolution.GP64在I组杆状病毒进化中起主要作用的证据。
Virus Res. 2009 Jun;142(1-2):85-91. doi: 10.1016/j.virusres.2009.01.015. Epub 2009 Jan 31.
10
The conserved baculovirus protein p33 (Ac92) is a flavin adenine dinucleotide-linked sulfhydryl oxidase.保守的杆状病毒蛋白p33（Ac92）是一种黄素腺嘌呤二核苷酸连接的巯基氧化酶。
Virology. 2009 Jun 5;388(2):231-5. doi: 10.1016/j.virol.2009.04.006. Epub 2009 May 1.