9-（2-羟乙氧甲基）鸟嘌呤对兔疱疹病毒性角膜炎和虹膜炎的作用
Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits.
作者信息
Kaufman H E, Varnell E D, Centifanto Y M, Rheinstrom S D
出版信息
Antimicrob Agents Chemother. 1978 Dec;14(6):842-5. doi: 10.1128/AAC.14.6.842.
Abstract
Drugs used for the inhibition of DNA viruses, such as iododeoxyuridine, adenine arabinoside, or trifluorothymidine, are not biochemically selective in their action and also interfere with normal cellular functions. The recently reported 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) is selectively phosphorylated by viral thymidine kinase but not by normal cellular thymidine kinase. Our present studies show that the acycloguanosine is as effective in treating herpetic keratitis in the rabbit as iododeoxyuridine and trifluorothymidine when given topically as an ointment. It is also effective when given intravenously for the treatment of herpetic iritis and is effective in preventing death from encephalitis in rabbits.
摘要
用于抑制DNA病毒的药物，如碘脱氧尿苷、阿糖腺苷或三氟胸苷，其作用在生化方面没有选择性，还会干扰正常细胞功能。最近报道的9-(2-羟乙氧甲基)鸟嘌呤（无环鸟苷）可被病毒胸苷激酶选择性磷酸化，但不能被正常细胞胸苷激酶磷酸化。我们目前的研究表明，无环鸟苷以软膏形式局部给药时，在治疗兔疱疹性角膜炎方面与碘脱氧尿苷和三氟胸苷一样有效。静脉给药治疗疱疹性虹膜炎也有效，并且在预防兔脑炎死亡方面也有效。
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本文引用的文献
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Clinical cure of herpes simplex keratitis by 5-iodo-2-deoxyuridine.5-碘-2-脱氧尿苷对单纯疱疹性角膜炎的临床治愈作用
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THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.5-三氟甲基-2'-脱氧尿苷在单纯疱疹性角膜炎中的治疗性抗病毒作用。
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Intravenous adenine arabinoside against herpes simplex keratouveitis in humans.静脉注射阿糖腺苷治疗人类单纯疱疹性角膜葡萄膜炎。
Am J Ophthalmol. 1975 Apr;79(4):659-64. doi: 10.1016/0002-9394(75)90807-7.
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9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.9-（2-羟乙氧甲基）鸟嘌呤对疱疹病毒组病毒的活性。
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Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.一种抗疱疹剂9-(2-羟乙氧甲基)鸟嘌呤的作用选择性
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Therapy of experimental herpes simplex keratitis in rabbits with 5-lodo-5'-amino-2',5'-dideoxyuridine (39882).用5-碘-5'-氨基-2',5'-二脱氧尿苷（39882）治疗兔实验性单纯疱疹性角膜炎
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