RNA病毒准种群体能够抑制远为优越的突变后代。
RNA virus quasispecies populations can suppress vastly superior mutant progeny.
作者信息
de la Torre J C, Holland J J
机构信息
Institute of Molecular Genetics, University of California, San Diego, La Jolla 92093.
出版信息
J Virol. 1990 Dec;64(12):6278-81. doi: 10.1128/JVI.64.12.6278-6281.1990.
Abstract
A variant clone of vesicular stomatitis virus recovered from a high-passage, evolving virus population replicated rapidly and produced remarkably high yields of virus, but these variants never dominated during further passages. We show that this clone is highly competitive, but it can overwhelm its progenitor population only when seeded above threshold level during dilute passages.
摘要
从高代次、不断进化的病毒群体中分离出的水疱性口炎病毒变异克隆株复制迅速，产生的病毒产量极高，但这些变异株在后续传代过程中从未占据主导地位。我们发现，该克隆株具有高度竞争力，但只有在稀释传代时接种量高于阈值水平时，它才能战胜其亲代群体。
相似文献
1
RNA virus quasispecies populations can suppress vastly superior mutant progeny.RNA病毒准种群体能够抑制远为优越的突变后代。
J Virol. 1990 Dec;64(12):6278-81. doi: 10.1128/JVI.64.12.6278-6281.1990.
2
Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.基因瓶颈和种群传代导致RNA病毒出现显著的适应性差异。
J Virol. 1993 Jan;67(1):222-8. doi: 10.1128/JVI.67.1.222-228.1993.
3
Extreme fitness differences in mammalian and insect hosts after continuous replication of vesicular stomatitis virus in sandfly cells.水疱性口炎病毒在白蛉细胞中持续复制后，哺乳动物和昆虫宿主出现的极端适应性差异。
J Virol. 1995 Nov;69(11):6805-9. doi: 10.1128/JVI.69.11.6805-6809.1995.
4
Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness.导致病毒适应性丧失的基因瓶颈大小由初始群体平均适应性决定。
J Virol. 1995 May;69(5):2869-72. doi: 10.1128/JVI.69.5.2869-2872.1995.
5
Quantitative characterization of defective virus emergence by deep sequencing.通过深度测序对缺陷病毒出现进行定量表征。
J Virol. 2014 Mar;88(5):2623-32. doi: 10.1128/JVI.02675-13. Epub 2013 Dec 18.
6
Reproducible nonlinear population dynamics and critical points during replicative competitions of RNA virus quasispecies.RNA病毒准种复制竞争过程中可重复的非线性种群动态和临界点
J Mol Biol. 1996 Dec 6;264(3):465-71. doi: 10.1006/jmbi.1996.0654.
7
Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses.RNA病毒克隆群体的相对适应性和高度适应性的定量分析。
J Virol. 1991 Jun;65(6):2960-7. doi: 10.1128/JVI.65.6.2960-2967.1991.
8
The switch from transcription to replication of a negative-strand RNA virus.负链RNA病毒从转录到复制的转变。
Cold Spring Harb Symp Quant Biol. 1987;52:367-71. doi: 10.1101/sqb.1987.052.01.042.
9
Recovery of negative-strand RNA viruses from plasmid DNAs: a positive approach revitalizes a negative field.从质粒DNA中拯救负链RNA病毒：一种积极的方法重振了一个消极的领域。
Virology. 1998 Jul 20;247(1):1-6. doi: 10.1006/viro.1998.9250.
10
Exponential increases of RNA virus fitness during large population transmissions.RNA病毒在大规模群体传播期间适应性的指数增长。
Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5841-4. doi: 10.1073/pnas.92.13.5841.
引用本文的文献
1
Adaptive selection of quasispecies during passaging in chickens, mice, and ferrets results in host-specific strains for the H9N2 avian influenza virus.H9N2禽流感病毒在鸡、小鼠和雪貂体内传代过程中的准种适应性选择导致产生宿主特异性毒株。
J Virol. 2025 Jun 17;99(6):e0015125. doi: 10.1128/jvi.00151-25. Epub 2025 May 8.
2
SARS-CoV-2 mutant spectra as variant of concern nurseries: endless variation?作为关注变异株温床的新型冠状病毒2突变谱：变异无穷？
Front Microbiol. 2024 Mar 14;15:1358258. doi: 10.3389/fmicb.2024.1358258. eCollection 2024.
3
Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies.SARS-CoV-2 准种的谜题、挑战和信息库。
J Virol. 2023 Dec 21;97(12):e0151123. doi: 10.1128/jvi.01511-23. Epub 2023 Nov 21.
4
Intracellular Diversity of WNV within Circulating Avian Peripheral Blood Mononuclear Cells Reveals Host-Dependent Patterns of Polyinfection.西尼罗河病毒在循环鸟类外周血单核细胞内的细胞内多样性揭示了多感染的宿主依赖模式。
Pathogens. 2023 May 26;12(6):767. doi: 10.3390/pathogens12060767.
5
Intracellular diversity of WNV within circulating avian peripheral blood mononuclear cells reveals host-dependent patterns of polyinfection.西尼罗病毒在循环禽外周血单核细胞内的细胞内多样性揭示了宿主依赖性多感染模式。
bioRxiv. 2023 Jan 29:2023.01.27.525959. doi: 10.1101/2023.01.27.525959.
6
SARS-CoV-2 Mutant Spectra at Different Depth Levels Reveal an Overwhelming Abundance of Low Frequency Mutations.不同深度水平的新型冠状病毒2突变谱揭示低频突变的压倒性丰度。
Pathogens. 2022 Jun 8;11(6):662. doi: 10.3390/pathogens11060662.
7
A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.病毒是一个群落：负义 RNA 病毒群体中的多样性。
Microbiol Mol Biol Rev. 2022 Sep 21;86(3):e0008621. doi: 10.1128/mmbr.00086-21. Epub 2022 Jun 23.
8
From one to many: The within-host rise of viral variants.从一到多：病毒变体在宿主体内的出现
PLoS Pathog. 2021 Sep 2;17(9):e1009811. doi: 10.1371/journal.ppat.1009811. eCollection 2021 Sep.
9
Genomic diversity contributes to the neuroinvasiveness of the Yellow fever French neurotropic vaccine.基因组多样性导致黄热病法国嗜神经病毒株疫苗具有神经侵袭性。
NPJ Vaccines. 2021 Apr 26;6(1):64. doi: 10.1038/s41541-021-00318-3.
10
Quasispecies Theory in Virology.病毒学中的准种理论
J Virol. 2002 Jan 1;76(1):463-465. doi: 10.1128/JVI.76.1.463-465.2002.
本文引用的文献
1
COXSACKIE A9 VIRUS: MUTATION FROM DRUG DEPENDENCE TO DRUG INDEPENDENCE.柯萨奇A9病毒：从依赖药物到不依赖药物的突变
Science. 1965 Apr 2;148(3666):97-8. doi: 10.1126/science.148.3666.97.
2
Rapid evolution of RNA genomes.RNA基因组的快速进化。
Science. 1982 Mar 26;215(4540):1577-85. doi: 10.1126/science.7041255.
3
Chemical basis of antigenic variation in foot-and-mouth disease virus.口蹄疫病毒抗原变异的化学基础。
Nature. 1983;306(5944):694-7. doi: 10.1038/306694a0.
4
High multiplicities of infection favor rapid and random evolution of vesicular stomatitis virus.高感染复数有利于水疱性口炎病毒的快速随机进化。
Virology. 1982 May;119(1):96-108. doi: 10.1016/0042-6822(82)90068-x.
5
Multiple genetic changes can occur in the oral poliovaccines upon replication in humans.
J Gen Virol. 1981 Oct;56(Pt 2):337-47. doi: 10.1099/0022-1317-56-2-337.
6
Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus.口蹄疫病毒自然群体中RNA的核苷酸序列异质性
Gene. 1980 Nov;11(3-4):333-46. doi: 10.1016/0378-1119(80)90073-6.
7
Similar frequencies of antigenic variants in Sendai, vesicular stomatitis, and influenza A viruses.仙台病毒、水疱性口炎病毒和甲型流感病毒中抗原变异体的频率相似。
Virology. 1980 Jul 15;104(1):235-8. doi: 10.1016/0042-6822(80)90382-7.
8
The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. II. Monoclonal antibodies of nonneutralizing and cross-reactive epitopes of Indiana and New Jersey serotypes.抗体与水疱性口炎病毒主要表面糖蛋白的相互作用。II. 印第安纳血清型和新泽西血清型非中和及交叉反应表位的单克隆抗体
Virology. 1982 Aug;121(1):168-74. doi: 10.1016/0042-6822(82)90126-x.
9
Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus.呼肠孤病毒温度敏感突变体的分离及初步遗传与生化特性分析
Virology. 1969 Mar;37(3):335-42. doi: 10.1016/0042-6822(69)90217-7.
10
Sequence analysis of the E2 gene of a hyperglycosylated, host restricted mutant of Sindbis virus and estimation of mutation rate from frequency of revertants.
Virology. 1986 Oct 15;154(1):135-43. doi: 10.1016/0042-6822(86)90436-8.
Zotero 插件