de la Torre J C, Holland J J
Institute of Molecular Genetics, University of California, San Diego, La Jolla 92093.
J Virol. 1990 Dec;64(12):6278-81. doi: 10.1128/JVI.64.12.6278-6281.1990.
A variant clone of vesicular stomatitis virus recovered from a high-passage, evolving virus population replicated rapidly and produced remarkably high yields of virus, but these variants never dominated during further passages. We show that this clone is highly competitive, but it can overwhelm its progenitor population only when seeded above threshold level during dilute passages.
从高代次、不断进化的病毒群体中分离出的水疱性口炎病毒变异克隆株复制迅速，产生的病毒产量极高，但这些变异株在后续传代过程中从未占据主导地位。我们发现，该克隆株具有高度竞争力，但只有在稀释传代时接种量高于阈值水平时，它才能战胜其亲代群体。
