P 波形态与心房局灶性心动过速起源的相关性——来自人体心房和躯干的真实模型的见解。
Correlation between P-wave morphology and origin of atrial focal tachycardia--insights from realistic models of the human atria and torso.
机构信息
Biological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, M13 9PL, UK.
出版信息
IEEE Trans Biomed Eng. 2011 Oct;58(10):2952-5. doi: 10.1109/TBME.2011.2161305. Epub 2011 Jul 7.
Abstract
Atrial arrhythmias resulting from abnormally rapid focal activity in the atria may be reflected in an altered P-wave morphology (PWM) in the ECG. Although clinically important, detailed relationships between PWM and origins of atrial focal excitations have not been established. To study such relationships, we developed computational models of the human atria and torso. The model simulation results were used to evaluate an extant clinical algorithm for locating the origin of atrial focal points from the ECG. The simulations showed that the algorithm was practical and could predict the atrial focal locations with 85% accuracy. We proposed a further refinement of the algorithm to distinguish between focal locations within the large atrial bundles.
摘要
心房内异常快速灶性活动引起的房性心律失常可能反映在心电图中的 P 波形态改变（PWM）中。尽管在临床上很重要，但 PWM 与心房灶性兴奋起源之间的详细关系尚未建立。为了研究这种关系，我们开发了人类心房和躯干的计算模型。使用模型模拟结果来评估一种现有的临床算法，用于从心电图定位心房灶点的起源。模拟结果表明，该算法具有实用性，可以以 85%的准确率预测心房灶点的位置。我们提出了对算法的进一步改进，以区分大心房束内的灶点位置。
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本文引用的文献
1
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2
The importance of atrial structure and fibers.心房结构和纤维的重要性。
Clin Anat. 2009 Jan;22(1):52-63. doi: 10.1002/ca.20634.
3
Normal atrial activation and voltage during sinus rhythm in the human heart: an endocardial and epicardial mapping study in patients with a history of atrial fibrillation.人类心脏窦性心律时的正常心房激活与电压：一项针对有房颤病史患者的心内膜和心外膜标测研究
J Cardiovasc Electrophysiol. 2007 Apr;18(4):402-8. doi: 10.1111/j.1540-8167.2007.00762.x.
4
Simulation of atrial electrophysiology and body surface potentials for normal and abnormal rhythm.正常和异常心律下心房电生理及体表电位的模拟
Conf Proc IEEE Eng Med Biol Soc. 2004;2004:817-20. doi: 10.1109/IEMBS.2004.1403283.
5
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6
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7
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Circ Res. 1998 Sep 7;83(5):541-51. doi: 10.1161/01.res.83.5.541.
10
Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model.人类心房动作电位特性的离子机制：来自数学模型的见解。
Am J Physiol. 1998 Jul;275(1):H301-21. doi: 10.1152/ajpheart.1998.275.1.H301.
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