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在高度多样化的环境中， spoligotyping 和可变数目串联重复序列分型对牛分枝杆菌分子溯源的局限性。

Limitations of spoligotyping and variable-number tandem-repeat typing for molecular tracing of Mycobacterium bovis in a high-diversity setting.

机构信息

Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain.

出版信息

J Clin Microbiol. 2011 Sep;49(9):3361-4. doi: 10.1128/JCM.00301-11. Epub 2011 Jul 13.

DOI:10.1128/JCM.00301-11
PMID:21752973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165628/
Abstract

This study describes the attempt to trace the first Mycobacterium bovis outbreak in alpacas (Lama pacos) in Spain by spoligotyping and variable-number tandem-repeat (VNTR) analysis. Due to high genotype diversity, no matching source was identified, but local expansion of a clonal group was found and its significance for molecular tracing is discussed.

摘要

本研究通过 spoligotyping 和可变数目串联重复（VNTR）分析，尝试追踪西班牙驼羊（Lama pacos）中的首例牛分枝杆菌爆发。由于基因型多样性较高，未发现匹配的来源，但发现了一个克隆群的本地扩张，并讨论了其对分子追踪的意义。

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本文引用的文献

1
Evaluation of mycobacterial interspersed repetitive-unit-variable-number tandem-repeat analysis and spoligotyping for genotyping of Mycobacterium bovis isolates and a comparison with restriction fragment length polymorphism typing.评价分枝杆菌间隔重复单位-可变数串联重复分析和 spoligotyping 用于牛分枝杆菌分离株的基因分型，并与限制性片段长度多态性分型进行比较。
J Clin Microbiol. 2010 Dec;48(12):4541-5. doi: 10.1128/JCM.01175-10. Epub 2010 Sep 29.
2
Genetic diversity of human isolates of Mycobacterium bovis assessed by spoligotyping and Variable Number Tandem Repeat genotyping.应用 spoligotyping 和可变数目串联重复基因分型评估牛分枝杆菌人分离株的遗传多样性。
Infect Genet Evol. 2011 Jan;11(1):175-80. doi: 10.1016/j.meegid.2010.09.004. Epub 2010 Sep 22.
3
Tuberculosis in alpacas (Lama pacos) caused by Mycobacterium bovis.绵羊型分枝杆菌引起的羊驼（羊驼属）结核病。
J Clin Microbiol. 2010 May;48(5):1960-4. doi: 10.1128/JCM.02518-09. Epub 2010 Mar 17.
4
Spatial distribution and risk factors of Brucellosis in Iberian wild ungulates.伊比利亚野生动物布氏杆菌病的空间分布和危险因素。
BMC Infect Dis. 2010 Mar 5;10:46. doi: 10.1186/1471-2334-10-46.
5
MIRU-VNTR typing adds discriminatory value to groups of Mycobacterium bovis and Mycobacterium caprae strains defined by spoligotyping.MIRU-VNTR 分型为 spoligotyping 定义的牛分枝杆菌和山羊分枝杆菌菌株群增加了鉴别价值。
Vet Microbiol. 2010 Jul 14;143(2-4):299-306. doi: 10.1016/j.vetmic.2009.11.027. Epub 2009 Nov 27.
6
Discriminatory ability of hypervariable variable number tandem repeat loci in population-based analysis of Mycobacterium tuberculosis strains, London, UK.高变区数目串联重复基因座在英国伦敦基于人群的结核分枝杆菌菌株分析中的鉴别能力。
Emerg Infect Dis. 2009 Oct;15(10):1609-16. doi: 10.3201/eid1510.090463.
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First data on Eurasian wild boar response to oral immunization with BCG and challenge with a Mycobacterium bovis field strain.关于欧亚野猪对卡介苗口服免疫及牛分枝杆菌田间菌株攻击的首次数据。
Vaccine. 2009 Nov 12;27(48):6662-8. doi: 10.1016/j.vaccine.2009.08.095. Epub 2009 Sep 9.
8
High spoligotype diversity within a Mycobacterium bovis population: clues to understanding the demography of the pathogen in Europe.高结核分枝杆菌种群的 spoligotype 多样性：了解该病原体在欧洲的种群动态的线索。
Vet Microbiol. 2010 Feb 24;141(1-2):89-95. doi: 10.1016/j.vetmic.2009.08.007. Epub 2009 Aug 8.
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Molecular typing of Mycobacterium bovis strains isolated in Italy from 2000 to 2006 and evaluation of variable-number tandem repeats for geographically optimized genotyping.2000年至2006年在意大利分离出的牛分枝杆菌菌株的分子分型以及对可变数目串联重复序列用于地理优化基因分型的评估。
J Clin Microbiol. 2009 Mar;47(3):636-44. doi: 10.1128/JCM.01192-08. Epub 2009 Jan 14.
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Persistence and molecular evolution of Mycobacterium bovis population from cattle and wildlife in Doñana National Park revealed by genotype variation.通过基因型变异揭示多尼亚纳国家公园牛和野生动物中牛分枝杆菌种群的持久性和分子进化
Vet Microbiol. 2008 Nov 25;132(1-2):87-95. doi: 10.1016/j.vetmic.2008.04.032. Epub 2008 Apr 30.