Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
Nano Lett. 2011 Sep 14;11(9):3720-6. doi: 10.1021/nl201978c. Epub 2011 Aug 1.
We coated nanoparticles including iron oxide nanoparticles and quantum dots with phospholipid-PEG using the newly developed dual solvent exchange method and demonstrated that, compared with the conventional film hydration method, the coating efficiency and quality of coated nanoparticles can be significantly improved. A better control of surface coating density and the amount of reactive groups on nanoparticle surface is achieved, allowing conjugation of different moieties with desirable surface concentrations, thus facilitating biomedical applications of nanoparticles.
我们使用新开发的双溶剂交换法将包括氧化铁纳米粒子和量子点在内的纳米粒子用磷脂-聚乙二醇进行包覆，并证实与传统的薄膜水化法相比，包覆纳米粒子的包覆效率和质量可以得到显著提高。可以更好地控制表面包覆密度和纳米粒子表面反应基团的数量，从而实现不同部分以理想的表面浓度进行结合，从而促进纳米粒子的生物医学应用。
