Department of Applied Biochemistry, Konkuk University, Chungju, Chungbuk, Korea.
Phytother Res. 2011 Aug;25(8):1257-61. doi: 10.1002/ptr.3378. Epub 2011 Feb 7.
To investigate the effects of Coriolus versicolor extract (CVE) on infl ammatory bowel disease (IBD), ulcerative colitis was induced in male BALb/c mice by administering drinking water containing dextran-sulfate sodium (DSS). The mice were divided into the following four experimental groups: control, DSS-induced colitis, CVE treatment and CVE treatment + DSS-induced colitis. Mice receiving DSS treatment developed clinical and macroscopic signs of ulcerative colitis. However, treatment with CVE relieved the symptoms of IBD, including the decrease in body and organ weight. The levels of serum, spleen and mesenteric lymph node IgE in the CVE-treated groups was lower compared with the untreated groups. The antiinfl ammatory response upon CVE treatment correlated with the reduced expression of TNF-α, IL-1β and IL-6. Also, there was a significant reduction in the expression of STAT1 and STAT6 molecules, thereby leading to lower IFN-γ and IL-4 expression. Therefore, the antiinfl ammatory effects of Coriolus versicolor can be explained by its ability to inhibit certain proinflammatory cytokines.
为了研究云芝提取物（CVE）对炎症性肠病（IBD）的影响，通过给予含有葡聚糖硫酸钠（DSS）的饮用水诱导雄性 BALB/c 小鼠发生溃疡性结肠炎。将小鼠分为以下四个实验组：对照组、DSS 诱导的结肠炎组、CVE 治疗组和 CVE 治疗+DSS 诱导的结肠炎组。接受 DSS 治疗的小鼠出现溃疡性结肠炎的临床和宏观症状。然而，CVE 治疗缓解了 IBD 的症状，包括体重和器官重量的减轻。与未治疗组相比，CVE 治疗组血清、脾脏和肠系膜淋巴结 IgE 水平降低。CVE 治疗的抗炎反应与 TNF-α、IL-1β 和 IL-6 的表达减少相关。此外，STAT1 和 STAT6 分子的表达显著降低，从而导致 IFN-γ 和 IL-4 的表达降低。因此，云芝的抗炎作用可以通过其抑制某些促炎细胞因子的能力来解释。
