Hammuel Chrinius, Yebpella Gary G, Shallangwa Gideon A, Magomya Asabe M, Agbajp Abel S
Environmental Services Division, National Research Institute for Chemical Technology, Zaria-Nigeria.
Acta Pol Pharm. 2011 Jul-Aug;68(4):535-9.
The methanol and the aqueous extracts of the plant, Agave sisalana were prepared and evaluated for its phytochemical properties and antimicrobial activities. The phytochemical analysis of the preparation revealed the presence of some secondary metabolites which include: saponins, glycosides, cardiac glycosides, steroids, tannins and flavonoids. The in vitro antimicrobial activity of the crude methanol and aqueous extract of the Agave sisalana were investigated. The extract showed antimicrobial activities against the test organisms with different zones of inhibition ranging from 28-32 mm and 25-29 mm for methanol and aqueous extract, respectively. The minimum inhibitory concentration (MIC) of both the methanol and aqueous extract was between 10-20 mg/mL, and the minimum bactericidal concentration (MBC) was between 20-40 mg/mL for both extracts. The investigation indicated that the methanol extract inhibited the growth of the microbes more than the aqueous extract. The ability of the crude extracts of A. sisalana to inhibit the growth of the microbes is an indication of its antimicrobial potential, which may be employed in the management of microbial infections.
制备了龙舌兰的甲醇提取物和水提取物，并对其植物化学性质和抗菌活性进行了评估。制剂的植物化学分析表明存在一些次生代谢产物，包括：皂苷、糖苷、强心苷、甾体、单宁和黄酮类化合物。研究了龙舌兰粗甲醇提取物和水提取物的体外抗菌活性。提取物对受试微生物显示出抗菌活性，甲醇提取物和水提取物的抑菌圈分别为28 - 32毫米和25 - 29毫米。甲醇提取物和水提取物的最低抑菌浓度（MIC）均在10 - 20毫克/毫升之间，两种提取物的最低杀菌浓度（MBC）均在20 - 40毫克/毫升之间。研究表明，甲醇提取物比水提取物更能抑制微生物的生长。龙舌兰粗提取物抑制微生物生长的能力表明其具有抗菌潜力，可用于治疗微生物感染。
