• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一些市售脱氧雪腐镰刀菌烯醇（DON）和玉米赤霉烯酮（ZEN）免疫亲和柱对 DON 和 ZEN 轭合物及代谢物的交叉反应性。

Cross-reactivity of some commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns to DON- and ZEN-conjugated forms and metabolites.

机构信息

Veterinary and Agrochemical Research Centre (CODA-CERVA), Operational Direction Chemical Safety of the Food Chain, Unit of Toxins and Natural Compounds, Leuvensesteenweg 17, B-3080 Tervuren, Belgium.

出版信息

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Dec;28(12):1687-93. doi: 10.1080/19440049.2011.603364. Epub 2011 Aug 1.

DOI:10.1080/19440049.2011.603364
PMID:21801078
Abstract

Seven commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns (IACs) were tested for cross-reactivity to conjugated forms (3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, DON-3-glucoside, DON-3-glucuronide, ZEN-glucosides, ZEN-glucuronide) and metabolites (de-epoxydeoxynivalenol, α-zearalenol, β-zearalenol) and nivalenol (NIV), using a semi-quantitative multi-mycotoxin ultra-performance liquid chromatography-tandem mass spectrometry method. The DON IACs showed cross-reactivity for nearly all DON derivatives tested. The ZEN IACs showed limited cross-reactivity to some of the ZEN derivatives. The IACs were evaluated for their potential use as sample clean-up for mycotoxins in serum.

摘要

七种市售的脱氧雪腐镰刀菌烯醇（DON）和玉米赤霉烯酮（ZEN）免疫亲和柱（IAC）用于检测与共轭形式（3-乙酰-DON、15-乙酰-DON、DON-3-葡糖苷、DON-3-葡萄糖醛酸苷、ZEN-葡糖苷、ZEN-葡萄糖醛酸苷）和代谢物（脱环氧脱氧雪腐镰刀菌烯醇、α-玉米赤霉烯醇、β-玉米赤霉烯醇）和雪腐镰刀菌烯醇（NIV）的交叉反应性，使用半定量多真菌毒素超高效液相色谱-串联质谱法。DON IAC 对几乎所有测试的 DON 衍生物均表现出交叉反应性。ZEN IAC 对一些 ZEN 衍生物表现出有限的交叉反应性。评估了 IAC 作为血清中真菌毒素样品净化的潜在用途。

相似文献

1
Cross-reactivity of some commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns to DON- and ZEN-conjugated forms and metabolites.一些市售脱氧雪腐镰刀菌烯醇（DON）和玉米赤霉烯酮（ZEN）免疫亲和柱对 DON 和 ZEN 轭合物及代谢物的交叉反应性。
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Dec;28(12):1687-93. doi: 10.1080/19440049.2011.603364. Epub 2011 Aug 1.
2
Occurrence of Mycotoxins and Their Modified Forms in Forage Maize Cultivars.饲用玉米品种中霉菌毒素及其修饰形式的发生。
Toxins (Basel). 2021 Feb 2;13(2):110. doi: 10.3390/toxins13020110.
3
Development of a multi-toxin method for investigating the carryover of zearalenone, deoxynivalenol and their metabolites into milk of dairy cows.开发一种多毒素方法，用于研究玉米赤霉烯酮、脱氧雪腐镰刀菌烯醇及其代谢产物在奶牛乳汁中的残留情况。
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(3):371-80. doi: 10.1080/19440049.2015.1011714.
4
New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone.深入研究黄曲霉毒素和玉米赤霉烯酮在人体代谢中的新见解。
Toxicol Lett. 2013 Jun 20;220(1):88-94. doi: 10.1016/j.toxlet.2013.04.012. Epub 2013 Apr 23.
5
Effect of ensiling duration on the fate of deoxynivalenol, zearalenone and their derivatives in maize silage.青贮时间对玉米青贮中脱氧雪腐镰刀菌烯醇、玉米赤霉烯酮及其衍生物命运的影响。
Mycotoxin Res. 2020 May;36(2):127-136. doi: 10.1007/s12550-019-00378-4. Epub 2019 Nov 8.
6
Development and application of analytical methods for the determination of mycotoxins in organic and conventional wheat.有机和传统小麦中霉菌毒素测定分析方法的开发与应用
Food Addit Contam. 2006 Nov;23(11):1208-18. doi: 10.1080/02652030600699312.
7
Survey of natural occurrence of trichothecene mycotoxins and zearalenone in Korean cereals harvested in 1992 using gas chromatography/mass spectrometry.运用气相色谱/质谱联用技术对1992年收获的韩国谷物中单端孢霉烯族霉菌毒素和玉米赤霉烯酮的自然发生情况进行的调查。
Food Addit Contam. 1996 Apr;13(3):333-41. doi: 10.1080/02652039609374416.
8
Selectivity of commercial immunoaffinity columns for modified forms of the mycotoxin 4-deoxynivalenol (DON).商业免疫亲和柱对霉菌毒素4-脱氧雪腐镰刀菌烯醇（DON）修饰形式的选择性。
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:322-326. doi: 10.1016/j.jchromb.2017.07.017. Epub 2017 Jul 11.
9
Incidence of trichothecenes and zearalenone in poultry feed mixtures from Slovakia.斯洛伐克家禽饲料混合物中单端孢霉烯族毒素和玉米赤霉烯酮的发生率。
Int J Food Microbiol. 2005 Nov 15;105(1):19-25. doi: 10.1016/j.ijfoodmicro.2005.06.005. Epub 2005 Jul 19.
10
Simultaneous determination of deoxynivalenol, zearalenone, and their major masked metabolites in cereal-based food by LC-MS-MS.基于 LC-MS-MS 的谷物类食物中脱氧雪腐镰刀菌烯醇、玉米赤霉烯酮及其主要掩蔽代谢物的同时测定。
Anal Bioanal Chem. 2009 Nov;395(5):1347-54. doi: 10.1007/s00216-009-2873-y. Epub 2009 Jul 2.

引用本文的文献

1
Immunoaffinity Extraction and Alternative Approaches for the Analysis of Toxins in Environmental, Food or Biological Matrices.免疫亲和提取及用于分析环境、食品或生物基质中毒素的其他方法
Toxins (Basel). 2020 Dec 13;12(12):795. doi: 10.3390/toxins12120795.
2
Zearalenone and Metabolites in Livers of Turkey Poults and Broiler Chickens Fed with Diets Containing Fusariotoxins.黄曲霉毒素和玉米赤霉烯酮及其代谢物在采食含伏马菌素日粮的火鸡苗和肉鸡肝脏中的残留。
Toxins (Basel). 2020 Aug 15;12(8):525. doi: 10.3390/toxins12080525.
3
Appropriateness to set a group health based guidance value for nivalenol and its modified forms.
设定雪腐镰刀菌烯醇及其修饰形式基于群体健康的指导值是否合适。
EFSA J. 2017 Apr 19;15(4):e04751. doi: 10.2903/j.efsa.2017.4751. eCollection 2017 Apr.
4
..
Toxins (Basel). 2020 Jun 1;12(6):362. doi: 10.3390/toxins12060362.
5
A critical evaluation of health risk assessment of modified mycotoxins with a special focus on zearalenone.对具有特殊关注的黄曲霉毒素的改性真菌毒素的健康风险评估的批判性评价。
Mycotoxin Res. 2019 Feb;35(1):27-46. doi: 10.1007/s12550-018-0328-z. Epub 2018 Sep 13.
6
A QuEChERS-Based Liquid Chromatography-Tandem Mass Spectrometry Method for the Simultaneous Determination of Nine Zearalenone-Like Mycotoxins in Pigs.基于 QuEChERS 的液相色谱-串联质谱法同时测定猪中 9 种玉米赤霉烯酮类似真菌毒素
Toxins (Basel). 2018 Mar 20;10(3):129. doi: 10.3390/toxins10030129.
7
Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches.人类体内3/15 - 乙酰脱氧雪腐镰刀菌烯醇的水解命运：利用体外和离体方法揭示小肠和肝脏的特异性脱乙酰作用
Toxins (Basel). 2016 Jul 28;8(8):232. doi: 10.3390/toxins8080232.
8
Cross-reactivity features of deoxynivalenol (DON)-targeted immunoaffinity columns aiming to achieve simultaneous analysis of DON and major conjugates in cereal samples.旨在实现谷物样品中脱氧雪腐镰刀菌烯醇（DON）及其主要共轭物同时分析的DON靶向免疫亲和柱的交叉反应特性。
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jun;33(6):1053-62. doi: 10.1080/19440049.2016.1188436. Epub 2016 May 31.
9
Synthesis of zearalenone-16-β,D-glucoside and zearalenone-16-sulfate: A tale of protecting resorcylic acid lactones for regiocontrolled conjugation.玉米赤霉烯酮-16-β-D-葡萄糖苷和玉米赤霉烯酮-16-硫酸盐的合成：保护雷琐酸内酯进行区域控制键合的故事。
Beilstein J Org Chem. 2014 May 15;10:1129-34. doi: 10.3762/bjoc.10.112. eCollection 2014.
10
Development and evaluation of monoclonal antibodies for the glucoside of T-2 toxin (t2-glc).用于 T-2 毒素糖苷（t2-glc）的单克隆抗体的开发和评估。
Toxins (Basel). 2013 Jul 19;5(7):1299-313. doi: 10.3390/toxins5071299.