Stenderup A
Department of Medical Microbiology, University of Aarhus, Denmark.
Acta Odontol Scand. 1990 Feb;48(1):3-10. doi: 10.3109/00016359009012728.
Yeasts occur commonly in the oral cavity in healthy individuals. The prevalent species is Candida albicans (about 60-70% of all isolates). C. glabrata and C. tropicalis come next, followed by other Candida species and genera (Rhodotorula, Saccharomyces, etc.) which are all of rare occurrence and transient. The yeast flora increases in many patient groups, especially those who are immunocompromised. C. albicans is the most important species, being the cause of almost all cases of yeast infections in the region, often in association with other species. The number isolated from the oral cavity depends on testing site and methods used. C. albicans can be typed by means of serology (types A and B), by biotyping, by morphology, by means of sensitivity to killer factors, by electrophoretic karyotyping, DNA fragments, and immunoblotting. Such methods may be of value epidemiologically. Switching in Candida morphology is associated with changes in micromorphology and physiology. Several non-yeast fungi may affect the oral cavity, most frequently in association with lung or disseminated infections.
酵母菌在健康个体的口腔中普遍存在。最常见的菌种是白色念珠菌(约占所有分离菌株的60%-70%)。其次是光滑念珠菌和热带念珠菌,随后是其他念珠菌种属(红酵母属、酿酒酵母属等),这些都很少见且为短暂存在。在许多患者群体中,尤其是免疫功能低下者,酵母菌菌群会增加。白色念珠菌是最重要的菌种,几乎是该地区所有酵母菌感染病例的病因,且常与其他菌种相关。从口腔分离出的数量取决于检测部位和所用方法。白色念珠菌可通过血清学(A 型和 B 型)、生物分型、形态学、对杀伤因子的敏感性、电泳核型分析、DNA 片段分析和免疫印迹法进行分型。这些方法在流行病学上可能具有价值。念珠菌形态的转变与微观形态和生理学变化有关。几种非酵母菌真菌可能会影响口腔,最常见于与肺部感染或播散性感染相关的情况。