Research Department, National Institute of Sport, Expertise and Performance (INSEP), Paris, France.
PLoS One. 2011;6(7):e22748. doi: 10.1371/journal.pone.0022748. Epub 2011 Jul 28.
The objectives of the present investigation was to analyze the effect of two different recovery modalities on classical markers of exercise-induced muscle damage (EIMD) and inflammation obtained after a simulated trail running race. Endurance trained males (n = 11) completed two experimental trials separated by 1 month in a randomized crossover design; one trial involved passive recovery (PAS), the other a specific whole body cryotherapy (WBC) for 96 h post-exercise (repeated each day). For each trial, subjects performed a 48 min running treadmill exercise followed by PAS or WBC. The Interleukin (IL) -1 (IL-1), IL-6, IL-10, tumor necrosis factor alpha (TNF-α), protein C-reactive (CRP) and white blood cells count were measured at rest, immediately post-exercise, and at 24, 48, 72, 96 h in post-exercise recovery. A significant time effect was observed to characterize an inflammatory state (Pre vs. Post) following the exercise bout in all conditions (p<0.05). Indeed, IL-1β (Post 1 h) and CRP (Post 24 h) levels decreased and IL-1ra (Post 1 h) increased following WBC when compared to PAS. In WBC condition (p<0.05), TNF-α, IL-10 and IL-6 remain unchanged compared to PAS condition. Overall, the results indicated that the WBC was effective in reducing the inflammatory process. These results may be explained by vasoconstriction at muscular level, and both the decrease in cytokines activity pro-inflammatory, and increase in cytokines anti-inflammatory.
本研究的目的是分析两种不同恢复方式对模拟越野跑后运动诱导的肌肉损伤（EIMD）和炎症的经典标志物的影响。11 名耐力训练男性以随机交叉设计完成了两项实验，间隔 1 个月；一项试验涉及被动恢复（PAS），另一项试验涉及运动后 96 小时内进行全身冷冻疗法（WBC），每天重复一次。对于每个试验，受试者进行 48 分钟的跑步机运动，然后进行 PAS 或 WBC。在休息时、运动后即刻以及运动后 24、48、72 和 96 小时测量白细胞介素（IL）-1（IL-1）、IL-6、IL-10、肿瘤坏死因子-α（TNF-α）、C 反应蛋白（CRP）和白细胞计数。在所有条件下，运动后即刻（Pre 与 Post）观察到时间效应，表现为炎症状态（p<0.05）。实际上，与 PAS 相比，WBC 后 IL-1β（Post 1 h）和 CRP（Post 24 h）水平降低，IL-1ra（Post 1 h）增加。在 WBC 条件下（p<0.05），与 PAS 条件相比，TNF-α、IL-10 和 IL-6 保持不变。总体而言，结果表明 WBC 有效减少了炎症过程。这些结果可能是由于肌肉水平的血管收缩以及促炎细胞因子活性降低和抗炎细胞因子增加所致。
