Institute of Healthy Ageing, and GEE, University College London, London WC1E 6BT, UK.
Curr Opin Cell Biol. 2011 Dec;23(6):738-43. doi: 10.1016/j.ceb.2011.07.006. Epub 2011 Aug 9.
Reduction in nutrient intake without malnutrition can delay ageing and extend healthy life in diverse organisms from yeast to primates. This effect can be recapitulated by genetic or pharmacological dampening of the signal through nutrient signalling pathways, making them a promising target for intervention into human ageing and age-related diseases. Here we review the current knowledge of the interactions between nutrient signalling pathways and ageing, focusing on the findings emerged in the past few years.
减少营养摄入而不导致营养不良可以延缓从酵母到灵长类等各种生物的衰老并延长健康寿命。通过营养信号通路的遗传或药理学抑制来实现这种效果，可以使它们成为干预人类衰老和与年龄相关疾病的有希望的靶点。在这里，我们综述了营养信号通路与衰老之间相互作用的最新知识，重点介绍了过去几年中出现的发现。
