甾醇 A-E，来自担子菌 Stereum ostrea BCC 22955 培养物的新萜类化合物。
Sterostreins A-E, new terpenoids from cultures of the Basidiomycete Stereum ostrea BCC 22955.
机构信息
National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
出版信息
Org Lett. 2011 Sep 16;13(18):4886-9. doi: 10.1021/ol2019778. Epub 2011 Aug 17.
PMID:21848293
Abstract
Sterostreins A-E (1, 2, 3a/3b, 4, and 5), five novel terpenoids, were isolated from cultures of the mushroom fungus Stereum ostrea BCC 22955. Sterostrein A (1) exhibited antimalarial activity (IC(50) 2.3 μg/mL) and cytotoxicity (IC(50) 5.3-38 μg/mL).
摘要
从蘑菇真菌 Stereum ostrea BCC 22955 的培养物中分离得到了五个新型萜类化合物，分别为 Sterostreins A-E（1、2、3a/3b、4 和 5）。Sterostrein A（1）表现出抗疟活性（IC（50）2.3μg/mL）和细胞毒性（IC（50）5.3-38μg/mL）。
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