Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Mol Ecol. 2011 Oct;20(19):4109-22. doi: 10.1111/j.1365-294X.2011.05241.x. Epub 2011 Aug 31.
Co-divergence between host and parasites suggests that evolutionary processes act across similar spatial and temporal scales. Although there has been considerable work on the extent and correlates of co-divergence of RNA viruses and their mammalian hosts, relatively little is known about the extent to which virus evolution is determined by the phylogeographic history of host species. To test hypotheses related to co-divergence across a variety of spatial and temporal scales, we explored phylogenetic signatures in Andes virus (ANDV) sampled from Chile and its host rodent, Oligoryzomys longicaudatus. ANDV showed strong spatial subdivision, a phylogeographic pattern also recovered in the host using both spatial and genealogical approaches, and despite incomplete lineage sorting. Lineage structure in the virus seemed to be a response to current population dynamics in the host at the spatial scale of ecoregions. However, finer scale analyses revealed contrasting patterns of genetic structure across a latitudinal gradient. As predicted by their higher substitution rates, ANDV showed greater genealogical resolution than the rodent, with topological congruence influenced by the degree of lineage sorting within the host. However, despite these major differences in evolutionary dynamics, the geographic structure of host and virus converged across large spatial scales.
宿主和寄生虫的共同进化表明进化过程在相似的时空尺度上起作用。尽管已经有相当多的关于 RNA 病毒及其哺乳动物宿主的共同进化程度和相关性的研究，但对于病毒进化在多大程度上取决于宿主物种的系统地理历史，人们知之甚少。为了检验与各种时空尺度上的共同进化相关的假设，我们探索了从智利及其宿主啮齿动物长尾鼠(Oligoryzomys longicaudatus)中采集到的安第斯病毒(ANDV)的系统发育特征。ANDV 表现出强烈的空间分裂，这种系统地理模式也在宿主中通过空间和系统发生方法得到了恢复，尽管不完全谱系分类。病毒的谱系结构似乎是对宿主当前生态区空间尺度上的种群动态的一种反应。然而，更精细的尺度分析显示，在纬度梯度上存在着相反的遗传结构模式。与宿主相比，ANDV 的替代率较高，因此具有更高的系统发生分辨率，拓扑同构受宿主内谱系分类程度的影响。然而，尽管在进化动态方面存在这些主要差异，宿主和病毒的地理结构在大的空间尺度上还是趋同的。
