Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.
Jpn J Ophthalmol. 2011 Nov;55(6):620-4. doi: 10.1007/s10384-011-0085-4. Epub 2011 Sep 3.
We evaluated central retinal thickness (CRT) in diabetic macular edema (DME) using two different spectral-domain (SD) optical coherence tomography (OCT) instruments: the Cirrus and Spectralis OCTs.
CRT was measured in 63 eyes of 32 patients with DME using both instruments on the same day.
CRT measurements were significantly greater for the Spectralis than the Cirrus (p < 0.0003, n = 63, paired t test); mean CRT values were 382 ± 136 μm with the Cirrus and 394 ± 139 μm with the Spectralis. In eyes with poor best-corrected visual acuity (BCVA) (<20/40), mean CRT was 378 ± 130 μm with the Cirrus and 395 ± 139 μm with the Spectralis (p < 0.007, n = 29). In eyes with good acuity (equal to or better than 20/40), the mean CRT was 385 ± 142 μm with the Cirrus and 393 ± 140 μm with the Spectralis (p < 0.005, n = 34).
Foveal retinal thickness measurements may vary among SD-OCT devices. The differences between instruments could affect the results of a multicenter study.
我们使用两种不同的谱域（SD）光学相干断层扫描（OCT）仪器——Cirrus 和 Spectralis OCT 评估糖尿病性黄斑水肿（DME）的中心视网膜厚度（CRT）。
在同 1 天内使用这两种仪器对 32 例 DME 患者的 63 只眼进行 CRT 测量。
Spectralis 的 CRT 测量值明显大于 Cirrus（p < 0.0003，n = 63，配对 t 检验）；Cirrus 的 CRT 平均值为 382 ± 136μm，Spectralis 为 394 ± 139μm。在最佳矫正视力（BCVA）较差（<20/40）的眼中，Cirrus 的 CRT 平均值为 378 ± 130μm，Spectralis 为 395 ± 139μm（p < 0.007，n = 29）。在视力良好（等于或好于 20/40）的眼中，Cirrus 的 CRT 平均值为 385 ± 142μm，Spectralis 为 393 ± 140μm（p < 0.005，n = 34）。
SD-OCT 设备之间的黄斑视网膜厚度测量值可能存在差异。仪器之间的差异可能会影响多中心研究的结果。
