假诺卡氏菌 A-C，来自深海放线菌假诺卡氏菌 SCSIO 01299 的新型二氮杂蒽醌衍生物。
Pseudonocardians A-C, new diazaanthraquinone derivatives from a deap-sea actinomycete Pseudonocardia sp. SCSIO 01299.
机构信息
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, China.
出版信息
Mar Drugs. 2011;9(8):1428-1439. doi: 10.3390/md9081428. Epub 2011 Aug 23.
Pseudonocardians A-C (2-4), three new diazaanthraquinone derivatives, along with a previously synthesized compound deoxynyboquinone (1), were produced by the strain SCSIO 01299, a marine actinomycete member of the genus Pseudonocardia, isolated from deep-sea sediment of the South China Sea. The structures of compounds 1-4 were determined by mass spectrometry and NMR experiments (¹H, ¹³C, HSQC, and HMBC). The structure of compound 1, which was obtained for the first time from a natural source, was confirmed by X-ray analysis. Compounds 1-3 exhibited potent cytotoxic activities against three tumor cell lines of SF-268, MCF-7 and NCI-H460 with IC₅₀ values between 0.01 and 0.21 μm, and also showed antibacterial activities on Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Bacillus thuringensis SCSIO BT01, with MIC values of 1-4 μg mL⁻¹.
假诺卡氏菌 A-C（2-4），三种新的二氮杂蒽醌衍生物，以及之前合成的化合物去氧新醌（1），由一株海洋放线菌假诺卡氏菌 SCSIO 01299 产生，该放线菌分离自南海深海沉积物。化合物 1-4 的结构通过质谱和 NMR 实验（1H、13C、HSQC 和 HMBC）确定。化合物 1 的结构，首次从天然来源中获得，通过 X 射线分析得到证实。化合物 1-3 对 SF-268、MCF-7 和 NCI-H460 三种肿瘤细胞系表现出较强的细胞毒性，IC50 值在 0.01-0.21 μm 之间，对金黄色葡萄球菌 ATCC 29213、粪肠球菌 ATCC 29212 和苏云金芽孢杆菌 SCSIO BT01 也具有抗菌活性，MIC 值为 1-4 μg mL⁻¹。
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