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载姜黄素纤维素纳米粒的设计用于前列腺癌。

Design of curcumin loaded cellulose nanoparticles for prostate cancer.

机构信息

Cancer Biology Research Center, Sanford Research/University of South Dakota, Sioux Falls, SD 57104-0589, USA.

出版信息

Curr Drug Metab. 2012 Jan;13(1):120-8. doi: 10.2174/138920012798356952.

DOI:10.2174/138920012798356952
PMID:21892919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3632315/
Abstract

Prostate cancer (PC) is the most frequently diagnosed disease in men in the United States. Curcumin (CUR), a natural diphenol, has shown potent anti-cancer efficacy in various types of cancers. However, suboptimal pharmacokinetics and poor bioavailability limit its effective use in cancer therapeutics. Several successful CUR nanoformulations have recently been reported which improve upon these features; however, there is no personalized safe nanoformulation for prostate cancer. This study contributes two important scientific aspects of prostate cancer therapeutics. The first objective was to investigate the comparative cellular uptake and cytotoxicity evaluation of β-cyclodextrin (CD), hydroxypropyl methylcellulose (cellulose), poly(lactic-co-glycolic acid) (PLGA), magnetic nanoparticles (MNP), and dendrimer based CUR nanoformulations in prostate cancer cells. Curcumin loaded cellulose nanoparticles (cellulose-CUR) formulation exhibited the highest cellular uptake and caused maximum ultrastructural changes related to apoptosis (presence of vacuoles) in prostate cancer cells. Secondly, the anti-cancer potential of the cellulose-CUR formulation was evaluated in cell culture models using cell proliferation, colony formation and apoptosis (7-AAD staining) assays. In these assays, the cellulose-CUR formulation showed improved anti-cancer efficacy compared to free curcumin. Our study shows, for the first time, the feasibility of cellulose-CUR formulation and its potential use in prostate cancer therapy.

摘要

前列腺癌（PC）是美国男性中最常见的疾病。姜黄素（CUR）是一种天然的二酚，已在多种类型的癌症中显示出强大的抗癌功效。然而，其药代动力学不佳和生物利用度低限制了其在癌症治疗中的有效应用。最近已经报道了几种成功的 CUR 纳米制剂，这些制剂改善了这些特性；然而，对于前列腺癌还没有个性化的安全纳米制剂。本研究为前列腺癌治疗贡献了两个重要的科学方面。第一个目标是研究β-环糊精（CD）、羟丙基甲基纤维素（纤维素）、聚（乳酸-共-羟基乙酸）（PLGA）、磁性纳米颗粒（MNP）和基于树状聚合物的 CUR 纳米制剂在前列腺癌细胞中的比较细胞摄取和细胞毒性评价。载姜黄素的纤维素纳米粒（纤维素-CUR）制剂表现出最高的细胞摄取，并在前列腺癌细胞中引起与细胞凋亡（出现空泡）相关的最大超微结构变化。其次，在细胞培养模型中，通过细胞增殖、集落形成和细胞凋亡（7-AAD 染色）测定评估了纤维素-CUR 制剂的抗癌潜力。在这些测定中，纤维素-CUR 制剂与游离姜黄素相比表现出改善的抗癌功效。本研究首次表明了纤维素-CUR 制剂的可行性及其在前列腺癌治疗中的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce88/3632315/a0e17f77591b/nihms439713f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce88/3632315/a0e17f77591b/nihms439713f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce88/3632315/a3bf51423333/nihms439713f1.jpg
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