mRNA 监控简述。
A brief survey of mRNA surveillance.
机构信息
Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, 6431 Fannin Street, Houston, TX 77030, USA.
出版信息
Trends Biochem Sci. 2011 Nov;36(11):585-92. doi: 10.1016/j.tibs.2011.07.005. Epub 2011 Sep 6.
Abstract
Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.
摘要
有缺陷的 mRNA 比正常 mRNA 更快地降解，这个过程称为 mRNA 监控。真核细胞使用多种机制来检测 mRNA 的异常，并使用多种酶来优先降解它们。RNA 监控领域的最新进展提供了有关细胞如何确定哪些 mRNA 物种应该被破坏的新信息，以及细胞一旦做出这样的决定就标记 mRNA 的新机制。在这篇综述中，我们强调了我们对这些过程的理解的最新进展。
相似文献
1
A brief survey of mRNA surveillance.mRNA 监控简述。
Trends Biochem Sci. 2011 Nov;36(11):585-92. doi: 10.1016/j.tibs.2011.07.005. Epub 2011 Sep 6.
2
Analysis of cytoplasmic mRNA decay in Saccharomyces cerevisiae.酿酒酵母中细胞质mRNA衰变的分析。
Methods Enzymol. 2008;448:409-27. doi: 10.1016/S0076-6879(08)02620-7.
3
The zinc-finger transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay.锌指转录因子Sfp1标记特定类别的mRNA，并将它们的合成与细胞质降解联系起来。
Elife. 2024 Oct 2;12:RP90766. doi: 10.7554/eLife.90766.
4
Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny.核糖体动力学和 mRNA 周转，在细胞不断的审视下，这是一种复杂的关系。
Wiley Interdiscip Rev RNA. 2021 Nov;12(6):e1658. doi: 10.1002/wrna.1658. Epub 2021 May 5.
5
Messenger RNA regulation: to translate or to degrade.信使核糖核酸调控：翻译还是降解
EMBO J. 2008 Feb 6;27(3):471-81. doi: 10.1038/sj.emboj.7601977.
6
mRNA degradation machines in eukaryotic cells.真核细胞中的信使核糖核酸降解机制
Biochimie. 2002 Aug;84(8):821-37. doi: 10.1016/s0300-9084(02)01445-1.
7
Regulated and quality-control mRNA turnover pathways in eukaryotes.真核生物中受调控和质量控制的 mRNA 周转途径。
Biochem Soc Trans. 2010 Dec;38(6):1506-10. doi: 10.1042/BST0381506.
8
Quality control: Is there quality control of localized mRNAs?质量控制：局部 mRNA 是否有质量控制？
J Cell Biol. 2014 Mar 17;204(6):863-8. doi: 10.1083/jcb.201401059.
9
A Comparative Overview of the Role of Human Ribonucleases in Nonsense-Mediated mRNA Decay.人类核糖核酸酶在无意义介导的 mRNA 降解中的作用比较概述。
Genes (Basel). 2024 Oct 10;15(10):1308. doi: 10.3390/genes15101308.
10
Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.控制人类β-珠蛋白 mRNA 稳定性及其对β-地中海贫血表型的影响。
Haematologica. 2011 Jun;96(6):905-13. doi: 10.3324/haematol.2010.039206. Epub 2011 Feb 28.
引用本文的文献
1
The NEDD4-binding protein N4BP1 degrades mRNA substrates through the coding sequence independent of nonsense-mediated decay.与NEDD4结合的蛋白N4BP1通过编码序列降解mRNA底物，且不依赖于无义介导的mRNA降解。
J Biol Chem. 2024 Dec;300(12):107954. doi: 10.1016/j.jbc.2024.107954. Epub 2024 Nov 2.
2
Massively parallel identification of sequence motifs triggering ribosome-associated mRNA quality control.大规模平行鉴定触发核糖体相关 mRNA 质量控制的序列基序。
Nucleic Acids Res. 2024 Jul 8;52(12):7171-7187. doi: 10.1093/nar/gkae285.
3
Down-Regulation of Rice Glutelin by Gene Editing Decreases Carbohydrate Content and Grain Weight and Modulates Synthesis of Seed Storage Proteins during Seed Maturation.基因编辑下调水稻谷蛋白含量降低碳水化合物含量和粒重，并调节种子成熟过程中种子贮藏蛋白的合成。
Int J Mol Sci. 2023 Nov 29;24(23):16941. doi: 10.3390/ijms242316941.
4
Transcriptomic Response of Differentiating Porcine Myotubes to Thermal Stress and Donor Piglet Age.猪肌管分化对热应激和供体仔猪年龄的转录组反应。
Int J Mol Sci. 2023 Sep 2;24(17):13599. doi: 10.3390/ijms241713599.
5
Proteomic, Metabolomic, and Lipidomic Analyses of Lung Tissue Exposed to Mustard Gas.暴露于芥子气的肺组织的蛋白质组学、代谢组学和脂质组学分析。
Metabolites. 2022 Aug 30;12(9):815. doi: 10.3390/metabo12090815.
6
Chemical modifications to mRNA nucleobases impact translation elongation and termination.对mRNA核碱基的化学修饰会影响翻译延伸和终止。
Biophys Chem. 2022 Jun;285:106780. doi: 10.1016/j.bpc.2022.106780. Epub 2022 Feb 16.
7
The History and Challenges of Women in Genetics: A Focus on Non-Western Women.遗传学领域女性的历史与挑战：聚焦非西方女性
Front Genet. 2021 Nov 25;12:759662. doi: 10.3389/fgene.2021.759662. eCollection 2021.
8
In Silico Identification and Functional Characterization of Conserved miRNAs in the Genome of ..基因组中保守微小RNA的计算机鉴定与功能表征
Bioinform Biol Insights. 2021 Jun 27;15:11779322211027665. doi: 10.1177/11779322211027665. eCollection 2021.
9
Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer.新型小非编码调节 RNA 在免疫和癌症中的新兴作用。
RNA Biol. 2020 Aug;17(8):1196-1213. doi: 10.1080/15476286.2020.1737442. Epub 2020 Mar 18.
10
Mechanism of ribosome stalling during translation of a poly(A) tail.多聚腺苷酸尾翻译过程中核糖体停滞的机制。
Nat Struct Mol Biol. 2019 Dec;26(12):1132-1140. doi: 10.1038/s41594-019-0331-x. Epub 2019 Nov 25.
本文引用的文献
1
Reporter mRNAs cleaved by Rnt1p are exported and degraded in the cytoplasm.Rnt1p 切割的 Reporter mRNAs 在细胞质中被输出和降解。
Nucleic Acids Res. 2011 Nov;39(21):9357-67. doi: 10.1093/nar/gkr627. Epub 2011 Aug 5.
2
Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.无终止 mRNA 降解复合物 Dom34-Hbs1 与停滞的 80S 核糖体结合的结构。
Nat Struct Mol Biol. 2011 Jun;18(6):715-20. doi: 10.1038/nsmb.2057. Epub 2011 May 29.
3
The nuclear RNA polymerase II surveillance system targets polymerase III transcripts.核 RNA 聚合酶 II 监测系统靶向聚合酶 III 转录本。
EMBO J. 2011 May 4;30(9):1790-803. doi: 10.1038/emboj.2011.97. Epub 2011 Apr 1.
4
Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.Pelota、Hbs1 和 ABCE1 介导的哺乳动物空载 80S 核糖体和延伸复合物停滞的解离。
EMBO J. 2011 May 4;30(9):1804-17. doi: 10.1038/emboj.2011.93. Epub 2011 Mar 29.
5
Differential utilization of decapping enzymes in mammalian mRNA decay pathways.哺乳动物 mRNA 降解途径中脱帽酶的差异利用。
RNA. 2011 Mar;17(3):419-28. doi: 10.1261/rna.2439811. Epub 2011 Jan 11.
6
Multiple mRNA decapping enzymes in mammalian cells.哺乳动物细胞中的多种 mRNA 去帽酶。
Mol Cell. 2010 Nov 12;40(3):423-32. doi: 10.1016/j.molcel.2010.10.010.
7
Unique properties of the Mtr4p-poly(A) complex suggest a role in substrate targeting.Mtr4p-多（A）复合物的独特性质表明其在底物靶向中的作用。
Biochemistry. 2010 Dec 14;49(49):10357-70. doi: 10.1021/bi101518x. Epub 2010 Nov 19.
8
The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation.人细胞质 RNA 末端 U 转移酶 ZCCHC11 靶向组蛋白 mRNA 进行降解。
RNA. 2011 Jan;17(1):39-44. doi: 10.1261/rna.2252511. Epub 2010 Nov 4.
9
Control of translation efficiency in yeast by codon-anticodon interactions.通过密码子-反密码子相互作用控制酵母中的翻译效率。
RNA. 2010 Dec;16(12):2516-28. doi: 10.1261/rna.2411710. Epub 2010 Oct 22.
10
Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay.Dom34:Hbs1 促进亚基解离和肽酰-tRNA 脱落，以启动无意义衰变。
Science. 2010 Oct 15;330(6002):369-72. doi: 10.1126/science.1192430.
Zotero 插件