Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, 6431 Fannin Street, Houston, TX 77030, USA.
Trends Biochem Sci. 2011 Nov;36(11):585-92. doi: 10.1016/j.tibs.2011.07.005. Epub 2011 Sep 6.
Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.
有缺陷的 mRNA 比正常 mRNA 更快地降解,这个过程称为 mRNA 监控。真核细胞使用多种机制来检测 mRNA 的异常,并使用多种酶来优先降解它们。RNA 监控领域的最新进展提供了有关细胞如何确定哪些 mRNA 物种应该被破坏的新信息,以及细胞一旦做出这样的决定就标记 mRNA 的新机制。在这篇综述中,我们强调了我们对这些过程的理解的最新进展。