天然和合成微生物途径中的羧化酶。
Carboxylases in natural and synthetic microbial pathways.
机构信息
Institute for Genomic Biology, University of Illinois, Urbana, Illinois 61801, USA.
出版信息
Appl Environ Microbiol. 2011 Dec;77(24):8466-77. doi: 10.1128/AEM.05702-11. Epub 2011 Oct 14.
Abstract
Carboxylases are among the most important enzymes in the biosphere, because they catalyze a key reaction in the global carbon cycle: the fixation of inorganic carbon (CO₂). This minireview discusses the physiological roles of carboxylases in different microbial pathways that range from autotrophy, carbon assimilation, and anaplerosis to biosynthetic and redox-balancing functions. In addition, the current and possible future uses of carboxylation reactions in synthetic biology are discussed. Such uses include the possible transformation of the greenhouse gas carbon dioxide into value-added compounds and the production of novel antibiotics.
摘要
羧基酶是生物圈中最重要的酶之一，因为它们催化全球碳循环中的关键反应：无机碳（CO₂）的固定。这篇综述讨论了羧基酶在不同微生物途径中的生理作用，这些途径包括自养、碳同化、补料作用以及生物合成和氧化还原平衡功能。此外，还讨论了羧化反应在合成生物学中的当前和可能的未来用途。这些用途包括将温室气体二氧化碳转化为有价值的化合物和生产新型抗生素的可能性。
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