Lee Jae Y, Kim Myung C
Department of Veterinary Surgery, College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University, Daejeon 305–764, Korea.
J Vet Med Sci. 2012 Mar;74(3):335-9. doi: 10.1292/jvms.10-0501. Epub 2011 Nov 8.
The aim of the present study was to evaluate the anesthetic and cardiorespiratory effects of tiletamine/zolazepam and the effect of flumazenil on the recovery from tiletamine/zolazepam anesthesia in the pig. Six Landrace and Yorkshire cross-bred pigs (three females and three males, 3-4 months old) weighing 35.8 ± 1.7 kg were used in this study. Pigs were given tiletamine/zolazepam intramuscularly at a dose of 4.4 mg kg(-1) (2.2 mg kg(-1) tiletamine and 2.2 mg kg(-1) zolazepam) of body weight. Twenty minutes after the administration of tiletamine/zolazem, the pigs were given saline solution (control, Group TZ) or given flumazenil intravenously at a dose of 0.08 mg kg(-1) of body weight (Group TZF). Anesthesia and recovery times, scores of anesthetic effects and cardiorespiratory variables were recorded for each pig. There was a significant difference between the duration of tiletamine/zolazepam anesthesia with and without the antagonist. Flumazenil significantly shortened the recovery time. A significant difference in blood gas variables was observed between the two groups. The anesthetic effects induced by tiletamine/zolazepam could be reversed successfully and safely by flumazenil alone. Therefore, flumazenil administration could be considered in cases in which quick recovery is required in pigs.
本研究的目的是评估替来他明/唑拉西泮的麻醉和心肺效应，以及氟马西尼对猪从替来他明/唑拉西泮麻醉中恢复的影响。本研究使用了6头体重为35.8±1.7千克的长白猪和约克夏杂交猪（3头雌性和3头雄性，3 - 4月龄）。猪按体重4.4毫克/千克（替来他明2.2毫克/千克和唑拉西泮2.2毫克/千克）的剂量肌肉注射替来他明/唑拉西泮。在注射替来他明/唑拉西泮20分钟后，给猪注射生理盐水（对照组，TZ组）或按体重0.08毫克/千克的剂量静脉注射氟马西尼（TZF组）。记录每头猪的麻醉和恢复时间、麻醉效果评分以及心肺变量。使用拮抗剂和未使用拮抗剂时，替来他明/唑拉西泮的麻醉持续时间存在显著差异。氟马西尼显著缩短了恢复时间。两组之间观察到血气变量存在显著差异。替来他明/唑拉西泮诱导的麻醉效果可通过单独使用氟马西尼成功且安全地逆转。因此，在需要猪快速恢复的情况下，可以考虑使用氟马西尼。
