Optimum Therapeutics LLC, The Ohio State University Science Tech Village, Columbus, OH 43212, USA.
Nanomedicine (Lond). 2011 Nov;6(9):1605-20. doi: 10.2217/nnm.11.141.
Effectiveness of nanomedicines in cancer therapy is limited in part by inadequate delivery and transport in tumor interstitium. This article reviews the experimental approaches to improve nanomedicine delivery and transport in solid tumors. These approaches include tumor vasculature normalization, interstitial fluid pressure modulation, enzymatic extracellular matrix degradation, and apoptosis-inducing tumor priming technology. We advocate the latter approach due to its ease and practicality (accomplished with standard-of-care chemotherapy, such as paclitaxel) and tumor selectivity. Examples of applying tumor priming to deliver nanomedicines and to design drug/RNAi-loaded carriers are discussed.
纳米医学在癌症治疗中的疗效受到肿瘤间质中输送和转运不足的限制。本文综述了提高实体瘤中纳米医学输送和转运的实验方法。这些方法包括肿瘤血管正常化、间质液压力调节、酶解细胞外基质和诱导凋亡的肿瘤引发技术。我们主张采用后一种方法，因为它简便实用（与紫杉醇等常规化疗联合应用）且具有肿瘤选择性。讨论了应用肿瘤引发技术输送纳米药物和设计载药/RNAi 的载体的实例。
