携带有扩展谱β-内酰胺酶基因 blaBES₋₁ 的广宿主范围质粒 pRIO-5 的完整序列。
Complete sequence of broad-host-range plasmid pRIO-5 harboring the extended-spectrum-β-lactamase gene blaBES₋₁.
机构信息
Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Sud, K-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2012 Feb;56(2):1116-9. doi: 10.1128/AAC.00480-11. Epub 2011 Nov 14.
Abstract
Broad-host-range plasmid pRIO-5, harboring the extended-spectrum β-lactamase bla(BES-1) gene in Serratia marcescens, was fully sequenced. Analysis of the 12,957-bp sequence of this IncP6-type plasmid revealed that the bla(BES-1) gene was associated with two copies of the insertion sequence IS26. The promoter responsible for the bla(BES-1) expression was hybrid, made of a -35 box located inside the inverted repeat of IS26 and a -10 box inside a remnant of an insertion sequence.
摘要
在粘质沙雷氏菌中带有扩展谱β-内酰胺酶 bla（BES-1）基因的广宿主范围质粒 pRIO-5 已被完全测序。对这个 IncP6 型质粒的 12957bp 序列分析表明 bla（BES-1）基因与两个插入序列 IS26 有关。负责 bla（BES-1）表达的启动子是混合的，由位于 IS26 反向重复内部的 -35 框和插入序列残余物内部的 -10 框组成。
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