多发性硬化症患者疲劳的治疗：一种神经认知方法。
Treatment of fatigue in multiple sclerosis patients: a neurocognitive approach.
作者信息
Catalan Mauro, De Michiel Alessandra, Bratina Alessio, Mezzarobba Susanna, Pellegrini Lorella, Marcovich Roberto, Tamiozzo Francesca, Servillo Giovanna, Zugna Laura, Bosco Antonio, Sartori Arianna, Pizzolato Gilberto, Zorzon Marino
机构信息
Department of Medical, Surgical and Health Sciences, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy.
出版信息
Rehabil Res Pract. 2011;2011:670537. doi: 10.1155/2011/670537. Epub 2011 Sep 8.
The objective of the study was to treat fatigue in patients with multiple sclerosis (MS) by a neurocognitive rehabilitation program aimed at improving motor planning by using motor imagery (MI). Twenty patients with clinically definite MS complaining of fatigue were treated for five weeks with exercises of neurocognitive rehabilitation twice a week. Patients were evaluated by Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS), MSQoL54, Expanded Disability Status Scale (EDSS), and MS Functional Composite (MSFC). After treatment, a decrease in fatigue was detected with both FSS (P = 0.0001) and MFIS (P = 0.0001). MSFC (P = 0.035) and MSQoL54 (P = 0.002) scores improved compared to baseline. At six-month followup, the improvement was confirmed for fatigue (FSS, P = 0.0001; MFIS P = 0.01) and for the physical subscale of MSQoL54 (P = 0.049). No differences in disability scales were found. These results show that neurocognitive rehabilitation, based on MI, could be a strategy to treat fatigue in MS patients.
该研究的目的是通过一项神经认知康复计划来治疗多发性硬化症（MS）患者的疲劳，该计划旨在通过运用运动想象（MI）来改善运动规划。20名临床确诊为MS且抱怨疲劳的患者接受了为期五周的神经认知康复训练，每周两次。通过疲劳严重程度量表（FSS）、改良疲劳影响量表（MFIS）、MSQoL54、扩展残疾状态量表（EDSS）和MS功能综合量表（MSFC）对患者进行评估。治疗后，FSS（P = 0.0001）和MFIS（P = 0.0001）均显示疲劳有所减轻。与基线相比，MSFC（P = 0.035）和MSQoL54（P = 0.002）评分有所改善。在六个月的随访中，疲劳（FSS，P = 0.0001；MFIS，P = 0.01）和MSQoL54的身体亚量表（P = 0.049）的改善得到了证实。在残疾量表方面未发现差异。这些结果表明，基于MI的神经认知康复可能是治疗MS患者疲劳的一种策略。
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