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阿育吠陀草药与铅中毒。

Ayurvedic herbal medicine and lead poisoning.

机构信息

Yale Cancer Center, Section of Hematology, Yale University School of Medicine, New Haven, CT 06511, USA.

出版信息

J Hematol Oncol. 2011 Dec 20;4:51. doi: 10.1186/1756-8722-4-51.

DOI:10.1186/1756-8722-4-51
PMID:22185092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3259062/
Abstract

Although the majority of published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Ayurveda is a system of traditional medicine that is native to India and is used in many parts of world as an alternative to standard treatment regimens. Here, we report the case of a 58-year-old woman who presented with abdominal pain, anemia, liver function abnormalities, and an elevated blood lead level. The patient was found to have been taking the Ayurvedic medicine Jambrulin prior to presentation. Chemical analysis of the medication showed high levels of lead. Following treatment with an oral chelating agent, the patient's symptoms resolved and laboratory abnormalities normalized. This case highlights the need for increased awareness that some Ayurvedic medicines may contain potentially harmful levels of heavy metals and people who use them are at risk of developing associated toxicities.

摘要

虽然大多数已发表的铅中毒病例来自职业暴露,但一些传统药物也可能含有有毒量的铅。阿育吠陀是一种源自印度的传统医学体系,在世界许多地区被用作标准治疗方案的替代方法。在这里,我们报告了一例 58 岁女性的病例,她因腹痛、贫血、肝功能异常和血铅水平升高就诊。发现该患者在就诊前一直在服用阿育吠陀药物 Jambrulin。对药物的化学分析显示铅含量很高。在用口服螯合剂治疗后,患者的症状得到缓解,实验室异常恢复正常。本病例强调了需要提高认识,即一些阿育吠陀药物可能含有潜在有害水平的重金属,使用这些药物的人有发生相关毒性的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd2/3259062/1ee9be872372/1756-8722-4-51-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd2/3259062/aae333d0df20/1756-8722-4-51-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd2/3259062/978afced9cd8/1756-8722-4-51-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd2/3259062/1ee9be872372/1756-8722-4-51-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd2/3259062/aae333d0df20/1756-8722-4-51-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd2/3259062/978afced9cd8/1756-8722-4-51-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd2/3259062/1ee9be872372/1756-8722-4-51-3.jpg

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本文引用的文献

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Three cases of lead toxicity associated with consumption of ayurvedic medicines.三例与服用阿育吠陀药物相关的铅中毒病例。
Indian J Clin Biochem. 2010 Jul;25(3):326-9. doi: 10.1007/s12291-010-0051-9. Epub 2010 Aug 25.
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A young Indian male with abdominal pain.一位有腹痛的年轻印度男性。
Clin Toxicol (Phila). 2011 Mar;49(3):191-2. doi: 10.3109/15563650.2011.559474.
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Occult lead poisoning from Ayurvedic medicine produced, prescribed and purchased in India.在印度生产、开处方和购买的阿育吠陀药物导致的隐匿性铅中毒。
Unmasking herbal medication-induced lead poisoning in a geriatric patient with gastrointestinal symptoms.
揭示老年胃肠道症状患者中草药相关铅中毒。
BMJ Case Rep. 2023 Dec 12;16(12):e258065. doi: 10.1136/bcr-2023-258065.
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Mutagenic, Carcinogenic, and Teratogenic Effect of Heavy Metals.重金属的致突变、致癌和致畸作用。
Evid Based Complement Alternat Med. 2022 Oct 5;2022:8011953. doi: 10.1155/2022/8011953. eCollection 2022.
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Imported Ayurvedic Medicine and Lead Poisoning.进口阿育吠陀医学与铅中毒。
Intern Med. 2022 Nov 1;61(21):3313. doi: 10.2169/internalmedicine.9178-21. Epub 2022 Mar 26.
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Lead poisoning from Ayurvedic treatment: a further case. Ayurvedic 疗法导致的铅中毒:又一例。
Med Lav. 2021 Apr 20;112(2):162-167. doi: 10.23749/mdl.v112i2.10576.
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Case series and review of Ayurvedic medication induced liver injury.阿育吠陀药物性肝损伤的病例系列和综述。
BMC Complement Med Ther. 2021 Mar 13;21(1):91. doi: 10.1186/s12906-021-03251-z.
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Broadening the List of Differential Diagnosis for Acute Abdomen - a Case Report from Nepal.拓展急腹症的鉴别诊断清单——来自尼泊尔的病例报告
EJIFCC. 2020 Nov 20;31(4):347-353. eCollection 2020 Nov.
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Lead poisoning secondary to unprescribed ayurvedic medicine intake.因服用未开处方的阿育吠陀药物导致的铅中毒。
BMJ Case Rep. 2020 Oct 30;13(10):e238576. doi: 10.1136/bcr-2020-238576.
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Complementary and Alternative Medicine: A Cross-Sectional Observational Study in Pediatric Inpatients.补充和替代医学:一项针对儿科住院患者的横断面观察性研究。
J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18765119. doi: 10.1177/2515690X18765119.
Med J Aust. 2011 Feb 21;194(4):205-6. doi: 10.5694/j.1326-5377.2011.tb03776.x.
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Clin Chim Acta. 2011 Jan 14;412(1-2):213-4. doi: 10.1016/j.cca.2010.10.007. Epub 2010 Oct 13.
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Heavy metal induced oxidative stress & its possible reversal by chelation therapy.重金属诱导的氧化应激及其通过螯合疗法的可能逆转。
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