Department of Engineering, University of Wisconsin, Madison, 53706, USA.
Clin EEG Neurosci. 2011 Oct;42(4):259-65. doi: 10.1177/155005941104200412.
Over the past decade, electrocorticography (ECoG) has been used for a wide set of clinical and experimental applications. Recently, there have been efforts in the clinic to adapt traditional ECoG arrays to include smaller recording contacts and spacing. These devices, which may be collectively called "micro-ECoG" arrays, are loosely defined as intercranial devices that record brain electrical activity on the sub-millimeter scale. An extensible 3D-platform of thin film flexible micro-scale ECoG arrays appropriate for Brain-Computer Interface (BCI) application, as well as monitoring epileptic activity, is presented. The designs utilize flexible film electrodes to keep the array in place without applying significant pressure to the brain and to enable radial subcranial deployment of multiple electrodes from a single craniotomy. Deployment techniques were tested in non-human primates, and stimulus-evoked activity and spontaneous epileptic activity were recorded. Further tests in BCI and epilepsy applications will make the electrode platform ready for initial human testing.
在过去的十年中，脑皮层电图（ECoG）已经被广泛应用于临床和实验领域。最近，临床方面也在努力将传统的 ECoG 阵列进行适配，以包含更小的记录触点和间隔。这些设备，通常被称为“微 ECoG”阵列，其被定义为可记录亚毫米级脑电活动的颅内设备。本文提出了一种可扩展的薄膜柔性微尺度 ECoG 阵列 3D 平台，适用于脑机接口（BCI）应用以及监测癫痫活动。该设计利用柔性薄膜电极使阵列保持原位，而不会对大脑施加过大压力，并能够从单个开颅术向颅内深处部署多个电极。在非人类灵长类动物中测试了部署技术，并记录了刺激诱发的活动和自发的癫痫活动。在 BCI 和癫痫应用中的进一步测试将使该电极平台能够进行初步的人体测试。
