Organic and Macromolecular Chemistry, Department of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin Germany.
J Control Release. 2012 Jul 20;161(2):484-95. doi: 10.1016/j.jconrel.2011.12.040. Epub 2012 Jan 5.
Among the various polymeric architectures, dendritic polymers have received a substantial scientific focus for their highly branched, multifunctional, and well-defined structures. Dendritic scaffolds have found many applications for designing nanoscale drug/gene delivery carriers and constructing diagnostic and biosensor devices, and protein-resistant surfaces. A significant number of research groups across Europe share the common objective, yet in conspicuously individual ways, of utilizing such polymers for devising innovative biomedical tools and techniques. This review describes the European effort of finding the application of dendritic polymers as advanced generation therapeutics within the purview of nanomedicine.
在各种聚合结构中，树枝状聚合物因其高度支化、多功能和明确的结构而受到了大量的科学关注。树枝状支架在设计纳米级药物/基因传递载体以及构建诊断和生物传感器设备和抗蛋白表面方面有许多应用。欧洲的许多研究小组都有一个共同的目标，即用这些聚合物设计创新的生物医学工具和技术，但他们的方法却非常独特。这篇综述描述了欧洲在纳米医学范围内寻找树枝状聚合物作为先进治疗药物的应用的努力。
