Instituto de Biotecnologia, Universidade de Caxias do Sul, 95070560 Caxias do Sul, RS, Brazil.
Nutrients. 2010 Oct;2(10):1048-59. doi: 10.3390/nu2101048. Epub 2010 Oct 11.
It has been suggested that the dietary intake of antioxidant supplements could be a useful strategy to reduce the incidence of diseases associated with oxidative stress. The aim of present work is to study the possibility to obtain compounds with antioxidant activity from wine wastes using water as solvent. Results have shown that it is possible to obtain flavan-3-ol compounds from wine wastes both from V. vinifera (cv. Cabernet Sauvignon and Merlot) and V. labrusca (cv. Bordo and Isabella) species. The main phenolic compounds found in the extracts were catechin and epicatechin, followed by procyanidin B3, procyanidin B1, procyanidin B2, gallic acid, epigallocatechin, and procyanidin B4. All flavan-3-ol extracts showed significant in vitro and in vivo activities. It was found that the extracts were able to prevent lipid and protein oxidative damage in the cerebral cortex, cerebellum and hippocampus tissues of rats. Although further studies are necessary, these flavan-3-ol extracts show potential to be used to reduce the incidence of degenerative diseases associated with oxidative stress.
有人提出，摄入抗氧化补充剂可能是减少与氧化应激相关疾病发生的一种有用策略。本研究旨在探讨使用水作为溶剂从葡萄酒废物中获得具有抗氧化活性的化合物的可能性。结果表明，从酿酒葡萄（赤霞珠和梅洛）和美洲葡萄（品丽珠和伊莎贝拉）品种的葡萄酒废物中均可以获得黄烷-3-醇类化合物。提取物中发现的主要酚类化合物为儿茶素和表儿茶素，其次为原花青素 B3、原花青素 B1、原花青素 B2、没食子酸、表没食子儿茶素和原花青素 B4。所有黄烷-3-醇提取物均显示出显著的体外和体内活性。研究发现，提取物能够预防大鼠大脑皮质、小脑和海马组织中的脂质和蛋白质氧化损伤。尽管还需要进一步研究，但这些黄烷-3-醇提取物具有用于减少与氧化应激相关的退行性疾病发生率的潜力。
