Valenzuela P
Chiron Research Laboratories, Chiron Corporation, Everyville, Ca 94608.
Gastroenterol Jpn. 1990 Sep;25 Suppl 2:62-71. doi: 10.1007/BF02779931.
Hepatitis A virus is an enteric picornavirus. Its genome is a single stranded RNA molecule of positive-strand polarity of 7478 bases. This sequence codes for a polyprotein which is processed to give rise to viral proteins VP-1, VP-2, VP-3 and others. Hepatitis B virus, a major worldwide infectious and cancer promoting agent contains a DNA genome of 3226 base pairs that replicates by a reverse transcriptase via an RNA intermediate. Extensive sequencing and expression experiments have revealed four major genes named surface, core, polymerase and X which are coded in more than one reading frame. Furthermore, within a frame, proteins are expressed from multiple initiation codons resulting in several related products. The viral genome of hepatitis C virus (nonA-nonB), an elusive major infectious agent, has recently been cloned. This genome is a single positive-stranded RNA of at least 10,000 bases which codes for several antigens, some of them associated specifically with nonA-nonB hepatitis infections. The hepatitis D (delta) viral agent, an infectious agent requiring a hepadnarious for propagation, contains a covalently closed circular single-stranded RNA genome of 1167 nucleotides. This genome encodes the protein p24 and p27 that bind specifically to antisera from patients with chronic hepatitis D infections.
甲型肝炎病毒是一种肠道微小核糖核酸病毒。其基因组是一个由7478个碱基组成的正链极性单链RNA分子。该序列编码一种多蛋白，经加工后产生病毒蛋白VP - 1、VP - 2、VP - 3等。乙型肝炎病毒是一种在全球范围内主要的传染性和促癌病原体，其DNA基因组由3226个碱基对组成，通过逆转录酶经RNA中间体进行复制。广泛的测序和表达实验揭示了四个主要基因，即表面基因、核心基因、聚合酶基因和X基因，它们由多个阅读框编码。此外，在一个阅读框内，蛋白质从多个起始密码子表达，产生几种相关产物。丙型肝炎病毒（非甲非乙型）的病毒基因组，一种难以捉摸的主要传染因子，最近已被克隆。该基因组是一个至少10000个碱基的单正链RNA，编码几种抗原，其中一些抗原与非甲非乙型肝炎感染特异性相关。丁型（δ）肝炎病毒因子是一种需要嗜肝病毒才能繁殖的传染因子，其基因组为一个由1167个核苷酸组成的共价闭合环状单链RNA。该基因组编码与慢性丁型肝炎感染患者抗血清特异性结合的p24和p27蛋白。
