Department of Psychiatry, Chung Ang University, College of Medicine, Seoul, South Korea.
J Psychiatr Res. 2012 Apr;46(4):507-15. doi: 10.1016/j.jpsychires.2012.01.004. Epub 2012 Jan 25.
Patients with on-line game addiction (POGA) and professional video game players play video games for extended periods of time, but experience very different consequences for their on-line game play. Brain regions consisting of anterior cingulate, thalamus and occpito-temporal areas may increase the likelihood of becoming a pro-gamer or POGA. Twenty POGA, seventeen pro-gamers, and eighteen healthy comparison subjects (HC) were recruited. All magnetic resonance imaging (MRI) was performed on a 1.5 Tesla Espree MRI scanner (SIEMENS, Erlangen, Germany). Voxel-wise comparisons of gray matter volume were performed between the groups using the two-sample t-test with statistical parametric mapping (SPM5). Compared to HC, the POGA group showed increased impulsiveness and perseverative errors, and volume in left thalamus gray matter, but decreased gray matter volume in both inferior temporal gyri, right middle occipital gyrus, and left inferior occipital gyrus, compared with HC. Pro-gamers showed increased gray matter volume in left cingulate gyrus, but decreased gray matter volume in left middle occipital gyrus and right inferior temporal gyrus compared with HC. Additionally, the pro-gamer group showed increased gray matter volume in left cingulate gyrus and decreased left thalamus gray matter volume compared with the POGA group. The current study suggests that increased gray matter volumes of the left cingulate gyrus in pro-gamers and of the left thalamus in POGA may contribute to the different clinical characteristics of pro-gamers and POGA.
网络游戏成瘾患者（POGA）和职业电子游戏玩家都会长时间玩电子游戏，但他们在线游戏行为的后果却截然不同。前扣带、丘脑和枕颞区域的大脑区域可能会增加成为职业游戏玩家或 POGA 的可能性。研究招募了 20 名 POGA、17 名职业游戏玩家和 18 名健康对照组（HC）。所有磁共振成像（MRI）均在 1.5 特斯拉 Espree MRI 扫描仪（德国西门子公司）上进行。使用两样本 t 检验和统计参数映射（SPM5）对组间灰质体积进行了体素级比较。与 HC 相比，POGA 组表现出冲动性和坚持性错误增加，左丘脑灰质体积增加，而双侧颞下回、右中枕叶和左枕下回灰质体积减少。与 HC 相比，职业游戏玩家的左扣带回灰质体积增加，左中枕叶和右颞下回灰质体积减少。此外，与 POGA 组相比，职业游戏玩家组的左扣带回灰质体积增加，左丘脑灰质体积减少。目前的研究表明，职业游戏玩家左扣带回和 POGA 左丘脑灰质体积的增加可能有助于解释职业游戏玩家和 POGA 不同的临床特征。
