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1
IMP-type metallo-β-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons.革兰氏阴性杆菌中的 IMP 型金属β-内酰胺酶:分布、系统发育及与整合子的关联。
Crit Rev Microbiol. 2011 Aug;37(3):214-26. doi: 10.3109/1040841X.2011.559944. Epub 2011 Mar 29.
2
Metallo-β-lactamases: a last frontier for β-lactams?金属β-内酰胺酶:β-内酰胺类药物的最后一道防线?
Lancet Infect Dis. 2011 May;11(5):381-93. doi: 10.1016/S1473-3099(11)70056-1.
3
Detection of the KPC gene in Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii during a PCR-based nosocomial surveillance study in Puerto Rico.在波多黎各进行的基于 PCR 的医院感染监测研究中,检测了产碳青霉烯酶肠杆菌科细菌(包括大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌)中的 KPC 基因。
Antimicrob Agents Chemother. 2011 Jun;55(6):2968-70. doi: 10.1128/AAC.01633-10. Epub 2011 Mar 28.
4
Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.IMP-18 金属β-内酰胺酶在一株美国铜绿假单胞菌分离株中的遗传背景和生化特性研究。
Antimicrob Agents Chemother. 2011 Jan;55(1):140-5. doi: 10.1128/AAC.00858-10. Epub 2010 Nov 1.
5
Pulsed field gel electrophoresis: a review of application and interpretation in the molecular epidemiology of infectious disease.脉冲场凝胶电泳:在传染病分子流行病学中的应用和解释综述。
Infect Genet Evol. 2010 Oct;10(7):866-75. doi: 10.1016/j.meegid.2010.07.023. Epub 2010 Aug 6.
6
In169, a new class 1 integron that encoded bla(IMP-18) in a multidrug-resistant Pseudomonas aeruginosa isolate from Mexico.169 年,在一株来自墨西哥的多重耐药铜绿假单胞菌分离株中发现了一个新的 1 类整合子,该整合子编码 bla(IMP-18)。
Arch Med Res. 2010 May;41(4):235-9. doi: 10.1016/j.arcmed.2010.05.006.
7
Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France.法国耐头孢他啶铜绿假单胞菌中产生的超广谱β-内酰胺酶、金属β-内酰胺酶和超广谱头孢菌素酶的全国性调查。
Antimicrob Agents Chemother. 2010 Aug;54(8):3512-5. doi: 10.1128/AAC.01646-09. Epub 2010 Jun 14.
8
Gene cassettes and cassette arrays in mobile resistance integrons.移动性抗性整合子中的基因盒及盒阵列
FEMS Microbiol Rev. 2009 Jul;33(4):757-84. doi: 10.1111/j.1574-6976.2009.00175.x. Epub 2009 Apr 15.
9
INTEGRALL: a database and search engine for integrons, integrases and gene cassettes.INTEGRALL:一个关于整合子、整合酶和基因盒的数据库及搜索引擎。
Bioinformatics. 2009 Apr 15;25(8):1096-8. doi: 10.1093/bioinformatics/btp105. Epub 2009 Feb 19.
10
Surveillance of carbapenem-resistant Pseudomonas aeruginosa isolates from Puerto Rican Medical Center Hospitals: dissemination of KPC and IMP-18 beta-lactamases.对波多黎各医疗中心医院耐碳青霉烯类铜绿假单胞菌分离株的监测:KPC和IMP-18β-内酰胺酶的传播情况
Antimicrob Agents Chemother. 2009 Apr;53(4):1660-4. doi: 10.1128/AAC.01172-08. Epub 2009 Feb 2.

来自波多黎各的铜绿假单胞菌临床分离株中两种新型的 I 类整合子,含有 IMP-18 金属β-内酰胺酶基因。

Two novel class I integron arrays containing IMP-18 metallo-β-lactamase gene in Pseudomonas aeruginosa clinical isolates from Puerto Rico.

机构信息

Department of Microbiology and Medical Zoology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.

出版信息

Antimicrob Agents Chemother. 2012 Apr;56(4):2119-21. doi: 10.1128/AAC.05758-11. Epub 2012 Jan 30.

DOI:10.1128/AAC.05758-11
PMID:22290962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318352/
Abstract

During a β-lactam resistance surveillance study, 12 IMP-18-positive Pseudomonas aeruginosa isolates belonging to 9 different pulsed-field gel electrophoresis groups were identified. In nine isolates, a class I integron with a novel gene array was identified that contained bla(IMP-18) and bla(OXA-224), while in two isolates the class I integron contained bla(IMP-18) and bla(OXA-2) but in a new arrangement. Our findings show the dissemination of two novel class I integrons in P. aeruginosa from different regions of Puerto Rico.

摘要

在一项β-内酰胺类耐药性监测研究中,鉴定出 12 株属于 9 个不同脉冲场凝胶电泳群的 IMP-18 阳性铜绿假单胞菌。在 9 株菌中,鉴定出一个具有新型基因阵列的 I 类整合子,其中包含 bla(IMP-18)和 bla(OXA-224),而在另外 2 株菌中,I 类整合子包含 bla(IMP-18)和 bla(OXA-2),但排列方式不同。我们的研究结果表明,两种新型 I 类整合子在来自波多黎各不同地区的铜绿假单胞菌中传播。