Peden C J, Cowan F M, Bryant D J, Sargentoni J, Cox I J, Menon D K, Gadian D G, Bell J D, Dubowitz L M
Department of Diagnostic Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
J Comput Assist Tomogr. 1990 Nov-Dec;14(6):886-94. doi: 10.1097/00004728-199011000-00004.
Proton magnetic resonance spectroscopy (MRS) was used to study the brain of 2 normal and 15 abnormal infants aged from 33 weeks postmenstrual age (PMA) to 14 months postnatal age. Eleven of the infants were examined on at least two occasions. The principal clinical diagnoses in the abnormal infants were perinatal ischemic and hemorrhagic brain injury. All proton spectra demonstrated peaks that were assigned to N-acetylaspartate (NAA), choline containing compounds (Cho), and creatine plus phosphocreatine (Cr). The NAA/Cho and NAA/Cr ratios increased with age, while the Cho/Cr ratio decreased with age in the majority of infants. The NAA/Cho ratio was generally lower in abnormal infants, but the difference was not apparent before 40 weeks (PMA). This ratio was lowest in infants with the severest degree of neurological abnormality. Proton and phosphorus MRS was compared in seven infants. In those with severe brain lesions, early phosphorus spectra were abnormal. On follow-up the phosphorus spectra became normal, but the proton spectra showed persistently low NAA/Cho and NAA/Cr ratios. Proton MRS provides new information that may be complementary to phosphorus MRS in the diagnosis and monitoring of brain development in normal and neurologically damaged infants.
质子磁共振波谱（MRS）被用于研究2名正常婴儿和15名异常婴儿的大脑，这些婴儿的月经龄（PMA）从33周至出生后14个月。其中11名婴儿至少接受了两次检查。异常婴儿的主要临床诊断为围产期缺血性和出血性脑损伤。所有质子波谱均显示出可归属于N-乙酰天门冬氨酸（NAA）、含胆碱化合物（Cho）以及肌酸加磷酸肌酸（Cr）的峰。在大多数婴儿中，NAA/Cho和NAA/Cr比值随年龄增加，而Cho/Cr比值随年龄降低。异常婴儿的NAA/Cho比值通常较低，但在40周（PMA）之前差异不明显。该比值在神经异常程度最严重的婴儿中最低。对7名婴儿进行了质子和磷MRS的比较。在患有严重脑损伤的婴儿中，早期磷波谱异常。随访时磷波谱恢复正常，但质子波谱显示NAA/Cho和NAA/Cr比值持续较低。质子MRS提供了新的信息，在正常和神经受损婴儿的脑发育诊断和监测中，可能是对磷MRS的补充。
